Biocompatibility of the Biopolymer Cyanoflan for Applications in Skin Wound Healing

There is a great demand for the development of novel wound dressings to overcome the time and costs of wound care performed by a vast number of clinicians, especially in the current overburdened healthcare systems. In this study, Cyanoflan, a biopolymer secreted by a marine unicellular cyanobacteriu...

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Bibliographic Details
Published in:Marine drugs 2021-03, Vol.19 (3), p.147
Main Authors: Costa, Raquel, Costa, Luís, Rodrigues, Ilda, Meireles, Catarina, Soares, Raquel, Tamagnini, Paula, Mota, Rita
Format: Article
Language:English
Subjects:
antioxidant
Antioxidants
Apoptosis
Biocompatibility
Biological activity
Biomaterials
Biomedical materials
Biopolymers
Biosafety
Cell adhesion & migration
Cell migration
Cell viability
Cyanobacteria
Cyanoflan
Cytotoxicity
Endothelial cells
Evaluation
Fibroblasts
Flow cytometry
Hydrogels
Inflammation
Medical dressings
Motility
Peptides
Polymers
Reactive oxygen species
Regeneration
Regeneration (biological)
Skin
skin regeneration
Tissue engineering
wound dressings
Wound healing
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Summary:There is a great demand for the development of novel wound dressings to overcome the time and costs of wound care performed by a vast number of clinicians, especially in the current overburdened healthcare systems. In this study, Cyanoflan, a biopolymer secreted by a marine unicellular cyanobacterium, was evaluated as a potential biomaterial for wound healing. Cyanoflan effects on cell viability, apoptosis, and migration were assessed in vitro, while the effect on tissue regeneration and biosafety was evaluated in healthy Wistar rats. The cell viability and apoptosis of fibroblasts and endothelial cells was not influenced by the treatment with different concentrations of Cyanoflan, as observed by flow cytometry. Moreover, the presence of Cyanoflan did not affect cell motility and migratory capacity, nor did it induce reactive oxygen species production, even revealing an antioxidant behavior regarding the endothelial cells. Furthermore, the skin wound healing in vivo assay demonstrated that Cyanoflan perfectly adapted to the wound bed without inducing systemic or local oxidative or inflammatory reaction. Altogether, these results suggest that Cyanoflan is a promising biopolymer for the development of innovative applications to overcome the many challenges that still exist in skin wound healing.
ISSN:1660-3397
1660-3397
DOI:10.3390/md19030147