Milligram mass metrology for quantitative deposition of liquid samples

Quantitative dispensing of liquids by mass becomes increasingly difficult as sample volume decreases. Whereas ml quantities of liquid can be directly weighed as dispensed on an analytical balance or using pycnometer methods, μl samples are more challenging due to their milligram-scale mass and rapid...

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Bibliographic Details
Published in:Measurement. Sensors 2022-08, Vol.22, p.100380, Article 100380
Main Author: Shaw, Gordon A.
Format: Article
Language:English
Subjects:
Mass
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Summary:Quantitative dispensing of liquids by mass becomes increasingly difficult as sample volume decreases. Whereas ml quantities of liquid can be directly weighed as dispensed on an analytical balance or using pycnometer methods, μl samples are more challenging due to their milligram-scale mass and rapid evaporation. Here, a method for quantitative determination of the mass of μl liquid droplets is proposed. The weighing of a microcapillary pycnometer combined with traceable calibration masses and corrections for sample evaporation allows determination of the droplet mass on the order of 1 mg with relative combined expanded uncertainty of 0.3%.
ISSN:2665-9174
2665-9174
DOI:10.1016/j.measen.2022.100380