Targeting shared pathways in tauopathies and age-related macular degeneration: implications for novel therapies

The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular d...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2024-04, Vol.16, p.1371745-1371745
Main Authors: Rinaldi, Michele, Pezone, Antonio, Quadrini, Gaia Italia, Abbadessa, Gianmarco, Laezza, Maria Paola, Passaro, Maria Laura, Porcellini, Antonio, Costagliola, Ciro
Format: Article
Language:English
Subjects:
Age
age-related macular degeneration
Alzheimer’s disease
amyloid-β
Biomarkers
Brain
Central nervous system
Chronic traumatic encephalopathy
Dementia
Disease
drusen
Macular degeneration
Nervous system
Neurodegeneration
Neurodegenerative diseases
Neuropathology
Neuroscience
Oxidative stress
Pathology
Peptides
Proteins
Retina
Senescence
Signal transduction
Structure-function relationships
Tau protein
tauopathies
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Summary:The intricate parallels in structure and function between the human retina and the central nervous system designate the retina as a prospective avenue for understanding brain-related processes. This review extensively explores the shared physiopathological mechanisms connecting age-related macular degeneration (AMD) and proteinopathies, with a specific focus on tauopathies. The pivotal involvement of oxidative stress and cellular senescence emerges as key drivers of pathogenesis in both conditions. Uncovering these shared elements not only has the potential to enhance our understanding of intricate neurodegenerative diseases but also sets the stage for pioneering therapeutic approaches in AMD.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2024.1371745