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Improved antibacterial activity of topical gel-based on nanosponge carrier of cinnamon oil
Methods: The nanosponges were fabricated by solvent emulsion diffusion method and evaluated for Fourier transform infrared spectroscopy (FTIR) studies, particle size, field emission scanning electron microscopy studies (FE-SEM), in vitro dissolution studies, in vitro antibacterial studies, using aga...
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Published in: | Bioimpacts 2021-01, Vol.11 (1), p.23-31 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Methods: The nanosponges were fabricated by solvent emulsion diffusion method and evaluated for Fourier transform infrared spectroscopy (FTIR) studies, particle size, field emission scanning electron microscopy studies (FE-SEM), in vitro dissolution studies, in vitro antibacterial studies, using agar diffusion method, in vivo antibacterial activity and skin irritation studies and stability studies. Keywords: Nanosponge Antimicrobial Essential oil Skin irritation Stability Topical Introduction Antimicrobials are the natural or synthetic agents that hinder the growth of microorganisms or kills microorganisms.1 The excess use of antibiotics leads to antimicrobial resistance.2 As synthetic drugs have many disadvantages such as drug resistance and toxicity so, natural products or essentials oils can be used to overcome the side effects. Cinnamon leaf oil nanocream was formulated for topical application,12 chitosan-cinnamon oil nanoparticles were prepared for enhanced shelf life and controlled release,13 O/W emulsion of cinnamon oil nanoparticles was formulated for active food packaging applications14 and liposomes of cinnamon oil were formulated for methicillin-resistant Staphylococcus aureus (MRSA) biofilm.15 Nanosponges are spongy, virus size NPs with an average diameter (250 nm-1 pm in diameter). Researchers studied nanosponge formulations based on essential oils such as lemongrass oil was incorporated into NS for anti-fungal activity,16 Babchi oil in CD-NS to improve solubility, photo-stability, and safety of essential oil.17 To overcome the problems of cinnamon oil, the research aims to formulate CEO-loaded nanosponges incorporated in carbopol gel with increased antimicrobial activity and decreased skin irritation. |
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ISSN: | 2228-5660 2228-5652 2228-5660 |
DOI: | 10.34172/bi.2021.04 |