Frequency of oligosymptomatic gastrointestinal tract diseases and its relation to insulin-like growth factor I in idiopathic (non-GH-deficient) short stature children

There is a discussion about growth hormone therapy in idiopathic short stature (ISS) children. To diagnose ISS, it is necessary to exclude other diseases; gastrointestinal tract diseases (GIDs) are among them. However, GID symptoms may be scarce. The aim of the study was to evaluate the frequency of...

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Bibliographic Details
Published in:Archives of medical science 2021-01, Vol.17 (6), p.1663-1671
Main Authors: Stawerska, Renata, Kolasa-Kicińska, Marzena, Kolejwa, Michał, Smyczyńska, Joanna, Hilczer, Maciej, Czkwianianc, Elżbieta, Lewiński, Andrzej
Format: Article
Language:English
Subjects:
Clinical Research
gastrointestinal tract diseases
helicobacter pylori
insulin-like growth factor i
short stature
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Summary:There is a discussion about growth hormone therapy in idiopathic short stature (ISS) children. To diagnose ISS, it is necessary to exclude other diseases; gastrointestinal tract diseases (GIDs) are among them. However, GID symptoms may be scarce. The aim of the study was to evaluate the frequency of unexpected oligosymptomatic GIDs in ISS and assess their influence on auxological parameters and insulin-like growth factor I (IGF-I) concentration. The analysis included 101 children with ISS and 95 controls. All patients were tested for celiac disease (CD), inflammatory bowel disease (IBD), lactose malabsorption (LM), cystic fibrosis (CF), (HP) and sp. (Asc) infections, as well as (Calb) colonization, by applying simple blood and stool tests and gastrofiberoscopy. In 75.2% of short children, one or more than one GIDs listed above were diagnosed, with the highest frequency of: Calb (46.5%), LM (33.7%), HP (24.7%) and/or Asc (21.8%). The incidence of GIDs was significantly higher than in the control group. The GID frequency increases with the age of children. In most ISS children, the IGF-I SDS was below -1.0 and it was the lowest in children with HP ( < 0.05). High frequency of unexpected oligosymptomatic GIDs in children diagnosed with ISS indicates the need to search for gastrointestinal (GI) causes in each case of short stature in children. The pathomechanisms responsible for short stature in these cases may vary, although it seems that reduced production of IGF-I plays an important role.
ISSN:1734-1922
1896-9151
DOI:10.5114/aoms.2020.93809