Clinical presentation, MRI, histopathology and outcome in a cat with immune-mediated masticatory myositis

Case summary A 4-year-old female spayed domestic shorthair cat was presented with facial swelling, ocular discharge and intermittent bilateral exophthalmos. Haematology revealed mild eosinophilia. Serum biochemistry showed a markedly elevated creatine kinase activity. MRI of the head revealed diffus...

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Bibliographic Details
Published in:JFMS open reports 2021-07, Vol.7 (2), p.20551169211050037
Main Authors: Armellini, Marco, Sánchez, Lluís, Lorek, Andrea, Shelton, G Diane, De Risio, Luisa
Format: Article
Language:English
Subjects:
Case Report
Histopathology
Inflammatory diseases
Kinases
magnetic
Masticatory
Musculoskeletal diseases
myositis
resonance
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Summary:Case summary A 4-year-old female spayed domestic shorthair cat was presented with facial swelling, ocular discharge and intermittent bilateral exophthalmos. Haematology revealed mild eosinophilia. Serum biochemistry showed a markedly elevated creatine kinase activity. MRI of the head revealed diffuse and severe changes of the masticatory muscles, including irregular areas compatible with fluid or necrosis within the abnormal muscle tissue. Cytological analysis of the left temporal muscle revealed eosinophilic and macrophagic inflammation. Bacterial and fungal cultures were negative. Serological titres against Toxoplasma gondii were compatible with previous exposure. A canine ELISA against masticatory muscle type IIM fibre proteins was positive at 1:4000 (reference interval
ISSN:2055-1169
2055-1169
DOI:10.1177/20551169211050037