Cross Talk at the Cytoskeleton-Plasma Membrane Interface: Impact on Neuronal Morphology and Functions

The cytoskeleton and its associated proteins present at the plasma membrane not only determine the cell shape but also modulate important aspects of cell physiology such as intracellular transport including secretory and endocytic pathways. Continuous remodeling of the cell structure and intense com...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-11, Vol.21 (23), p.9133
Main Authors: Di Giaimo, Rossella, Penna, Eduardo, Pizzella, Amelia, Cirillo, Raffaella, Perrone-Capano, Carla, Crispino, Marianna
Format: Article
Language:English
Subjects:
Animals
Axons - metabolism
Cell Communication
Cell Membrane - metabolism
Cell size
Communication
Crosstalk
cystatin B
Cytology
Cytoskeleton
Cytoskeleton - metabolism
Disease Susceptibility
exosomes
Extracellular Vesicles
Humans
local protein synthesis
Membranes
Microscopy
Morphology
Nerve endings
Nervous system
Nervous System Diseases - etiology
Nervous System Diseases - metabolism
Neuronal Plasticity
Neurons
Neurons - physiology
Physiology
Plasma
plasma membrane
Polymerization
Protein Biosynthesis
Proteins
Review
Roles
Signal Transduction
Synapses
Synapses - metabolism
Synaptic plasticity
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Summary:The cytoskeleton and its associated proteins present at the plasma membrane not only determine the cell shape but also modulate important aspects of cell physiology such as intracellular transport including secretory and endocytic pathways. Continuous remodeling of the cell structure and intense communication with extracellular environment heavily depend on interactions between cytoskeletal elements and plasma membrane. This review focuses on the plasma membrane-cytoskeleton interface in neurons, with a special emphasis on the axon and nerve endings. We discuss the interaction between the cytoskeleton and membrane mainly in two emerging topics of neurobiology: (i) production and release of extracellular vesicles and (ii) local synthesis of new proteins at the synapses upon signaling cues. Both of these events contribute to synaptic plasticity. Our review provides new insights into the physiological and pathological significance of the cytoskeleton-membrane interface in the nervous system.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21239133