Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling

Melanoma is a highly aggressive cancer that can metastasize at early stage. The aim of this study is to clarify the role of Piezo1 and its potential mechanism in regulating the malignant phenotypes of melanoma. In the present study, we first showed that Piezo1 was abnormally expressed in melanoma, w...

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Bibliographic Details
Published in:Cancer biology & therapy 2022-12, Vol.23 (1), p.336-347
Main Authors: Zhang, Simei, Cao, Shuang, Gong, Mengyuan, Zhang, Wunai, Zhang, Weifan, Zhu, Zeen, Wu, Shuai, Yue, Yangyang, Qian, Weikun, Ma, Qingyong, Wang, Shengpeng, Wang, Zheng
Format: Article
Language:English
Subjects:
AKT/mTOR signaling
melanoma
metastasis
Piezo1
proliferation
Research Paper
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Summary:Melanoma is a highly aggressive cancer that can metastasize at early stage. The aim of this study is to clarify the role of Piezo1 and its potential mechanism in regulating the malignant phenotypes of melanoma. In the present study, we first showed that Piezo1 was abnormally expressed in melanoma, which accelerated the malignant progression by activating AKT/mTOR signaling. Firstly, we found that Piezo1 was upregulated in melanoma and associated with poor survival. Additionally, Piezo1 knockdown significantly weakened intracellular calcium signal and viability of melanoma cells. Furthermore, Piezo1 knockdown inhibited the transendothelial migration and invasion in vitro, as well as metastasis in vivo. Mechanistically, we found that Piezo1 activated AKT/mTOR signaling to maintain malignant phenotypes of melanoma. Therefore, Piezo1 acts as an oncogene in melanoma cells and provides a novel candidate for melanoma diagnosis and treatment.
ISSN:1538-4047
1555-8576
DOI:10.1080/15384047.2022.2060015