Novel sensing probe using Terbium-sensitized luminescence and 8-hydroxyquinoline for determination of prucalopride succinate: green assessment with Complex-GAPI and analytical Eco-Scale

A highly sensitive spectrofluorimetric method is developed for the determination of prucalopride succinate (PRU). The method depends on lanthanide-sensitized luminescence due to complex formation between the drug and terbium chloride (Tb +3 ) which is enhanced by the addition of 8 hydroxyquinoline (...

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Bibliographic Details
Published in:BMC chemistry 2022-10, Vol.16 (1), p.80-80, Article 80
Main Authors: Elshahed, Mona S., Toubar, Safaa S., Ashour, Azza A., El-Eryan, Rasha Th
Format: Article
Language:English
Subjects:
8-Hydroxyquinoline
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Complex formation
Drug dosages
Ethylenediaminetetraacetic acid
Hydroxyquinoline
Investigations
Ligands
Luminescence
Methods
Pharmaceutical industry
Phosphates
Prucalopride succinate
Rare earth metals
Software
Spectrofluorimetry
Terbium
Terbium chloride
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Summary:A highly sensitive spectrofluorimetric method is developed for the determination of prucalopride succinate (PRU). The method depends on lanthanide-sensitized luminescence due to complex formation between the drug and terbium chloride (Tb +3 ) which is enhanced by the addition of 8 hydroxyquinoline (8HQ) and phosphate buffer (0.02 M, pH 3.2). The calibration curve was constructed over the linear range 10–300 ng/mL after excitation at 226 nm and measuring the emission of the ternary complex at 544 nm. The method was validated according to ICH Q2 (R1) guidelines and showed a good recovery ± RSD of 100.41% ± 1.26, the limits of detection and quantitation were found to be 2.81 and 8.53 ng/mL, respectively. The proposed method was successfully applied for the determination of the drug marketed tablet dosage form and the results were in good agreement with the reference method. Also, the method greenness was evaluated according to Complex-GAPI and analytical Eco-Scale.
ISSN:2661-801X
2661-801X
DOI:10.1186/s13065-022-00876-0