Methods to Evaluate Skin Penetration In Vitro

Dermal and transdermal drug therapy is increasing in importance nowadays in drug development. To completely utilize the potential of this administration route, it is necessary to optimize the drug release and skin penetration measurements. This review covers the most well-known and up-to-date method...

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Bibliographic Details
Published in:Scientia pharmaceutica 2019-08, Vol.87 (3), p.19-21
Main Authors: Zsikó, Stella, Csányi, Erzsébet, Kovács, Anita, Budai-Szűcs, Mária, Gácsi, Attila, Berkó, Szilvia
Format: Article
Language:English
Subjects:
Cholesterol
CLSM
confocal Raman microscopy
Drug delivery systems
drug release
Franz cell
Methods
Microscopy
Pharmaceuticals
Skin
skin penetration
skin-PAMPA
Spectrum analysis
tape stripping
two-photon microscopy
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Summary:Dermal and transdermal drug therapy is increasing in importance nowadays in drug development. To completely utilize the potential of this administration route, it is necessary to optimize the drug release and skin penetration measurements. This review covers the most well-known and up-to-date methods for evaluating the cutaneous penetration of drugs in vitro as a supporting tool for pharmaceutical research scientists in the early stage of drug development. The aim of this article is to present various experimental models used in dermal/transdermal research and summarize the novel knowledge about the main in vitro methods available to study skin penetration. These techniques are: Diffusion cell, skin-PAMPA, tape stripping, two-photon microscopy, confocal laser scanning microscopy, and confocal Raman microscopic method.
ISSN:2218-0532
0036-8709
2218-0532
DOI:10.3390/scipharm87030019