Phenotypic and genotypic profile of pyrethroid resistance in populations of the mosquito Aedes aegypti from Goiânia, Central West Brazil

The mosquito Aedes aegypti has evolved resistance to pyrethroid insecticides. The present study evaluated Ae. aegypti from Goiânia for the resistant phenotype and for mutations associated with resistance. Insecticide dose-response bioassays were conducted on mosquitoes descended from field-collected...

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Published in:Revista da Sociedade Brasileira de Medicina Tropical 2015-09, Vol.48 (5), p.607-609
Main Authors: Chapadense, Francesca Guaracyaba Garcia, Fernandes, Everton Kort Kamp, Lima, José Bento Pereira, Martins, Ademir Jesus, Silva, Luana Carrara, Rocha, Welington Tristão da, Santos, Adelair Helena Dos, Cravo, Pedro
Format: Article
Language:English
Subjects:
Aedes - classification
Aedes - drug effects
Aedes - genetics
Aedes aegypti
Animals
Biological Assay
Brazil
Female
Genotype
Insecticide Resistance - genetics
Insecticides
Mutation - genetics
Nitriles
Phenotype
Polymerase Chain Reaction
Pyrethrins
Resistance
TROPICAL MEDICINE
Voltage-gated sodium channel
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Summary:The mosquito Aedes aegypti has evolved resistance to pyrethroid insecticides. The present study evaluated Ae. aegypti from Goiânia for the resistant phenotype and for mutations associated with resistance. Insecticide dose-response bioassays were conducted on mosquitoes descended from field-collected eggs, and polymerase chain reaction (PCR) was used to genotype 90 individuals at sites implicated in pyrethroid resistance. All mosquito populations displayed high levels of resistance to deltamethrin, as well as high frequencies of the 1016Ile kdr and 1534Cys kdrmutations. Aedes aegypti populations in the Goiânia area are highly resistant to deltamethrin, presumably due to high frequencies of kdr(knockdown-resistance) mutations.
ISSN:0037-8682
1678-9849
1678-9849
0037-8682
DOI:10.1590/0037-8682-0046-2015