Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Abstract Background Insulin, a pleotrophic hormone, has diverse effects in the body. Recent work has highlighted the important role of insulin's action in the nervous system on glucose and energy homeostasis, memory, and mood. Scope of review Here we review experimental and clinical work that h...

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Bibliographic Details
Published in:Molecular metabolism (Germany) 2016-08, Vol.5 (8), p.589-601
Main Authors: Lee, Seung-Hwan, Zabolotny, Janice M, Huang, Hu, Lee, Hyon, Kim, Young-Bum
Format: Article
Language:English
Subjects:
Endocrinology & Metabolism
Insulin
Intranasal insulin
Memory
Metabolism
Mood
Review
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Summary:Abstract Background Insulin, a pleotrophic hormone, has diverse effects in the body. Recent work has highlighted the important role of insulin's action in the nervous system on glucose and energy homeostasis, memory, and mood. Scope of review Here we review experimental and clinical work that has broadened the understanding of insulin's diverse functions in the central and peripheral nervous systems, including glucose and body weight homeostasis, memory and mood, with particular emphasis on intranasal insulin. Major conclusions Implications for the treatment of obesity, type 2 diabetes, dementia, and mood disorders are discussed in the context of brain insulin action. Intranasal insulin may have potential in the treatment of central nervous system-related metabolic disorders.
ISSN:2212-8778
2212-8778
DOI:10.1016/j.molmet.2016.06.011