Urinary pH is an independent predictor of upper tract recurrence in non-muscle-invasive bladder cancer patients with a smoking history

Limited information is currently available on predictors of upper tract urothelial carcinoma (UTUC) recurrence in non-muscle-invasive bladder cancer (NMIBC) patients according to smoking history, although smoking probably contributes to urothelial carcinogenesis. Therefore, the present study aimed t...

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Bibliographic Details
Published in:Scientific reports 2021-10, Vol.11 (1), p.20675-20675, Article 20675
Main Authors: Ide, Hiroki, Kikuchi, Eiji, Ogihara, Koichiro, Niwa, Naoya, Shigeta, Keisuke, Masuda, Tsukasa, Baba, Yuto, Mizuno, Ryuichi, Oya, Mototsugu
Format: Article
Language:English
Subjects:
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BCG Vaccine - therapeutic use
Bladder cancer
Carcinogenesis
Carcinoma, Transitional Cell - pathology
Cigarettes
Female
Humanities and Social Sciences
Humans
Hydrogen-Ion Concentration
Invasiveness
Male
multidisciplinary
Neoplasm Invasiveness - pathology
Neoplasm Recurrence, Local - pathology
pH effects
Population studies
Risk Factors
Science
Science (multidisciplinary)
Smoking
Smoking - pathology
Tumors
Ureteral Neoplasms - pathology
Urinary Bladder Neoplasms - pathology
Urothelial carcinoma
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Summary:Limited information is currently available on predictors of upper tract urothelial carcinoma (UTUC) recurrence in non-muscle-invasive bladder cancer (NMIBC) patients according to smoking history, although smoking probably contributes to urothelial carcinogenesis. Therefore, the present study aimed to identify independent predictors of UTUC recurrence in all patients and those with a smoking history. Our study population comprised 1190 NMIBC patients who underwent transurethral resection of bladder tumor. UTUC developed in 43 patients during the follow-up. A history of bacillus Calmette-Guérin (BCG) therapy was independently associated with a lower incidence of UTUC (HR = 0.43; P  = 0.011). In a subgroup of NMIBC patients with a smoking history, concomitant carcinoma in situ (CIS) and a lower urinary pH (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-00184-y