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Urinary pH is an independent predictor of upper tract recurrence in non-muscle-invasive bladder cancer patients with a smoking history
Limited information is currently available on predictors of upper tract urothelial carcinoma (UTUC) recurrence in non-muscle-invasive bladder cancer (NMIBC) patients according to smoking history, although smoking probably contributes to urothelial carcinogenesis. Therefore, the present study aimed t...
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Published in: | Scientific reports 2021-10, Vol.11 (1), p.20675-20675, Article 20675 |
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description | Limited information is currently available on predictors of upper tract urothelial carcinoma (UTUC) recurrence in non-muscle-invasive bladder cancer (NMIBC) patients according to smoking history, although smoking probably contributes to urothelial carcinogenesis. Therefore, the present study aimed to identify independent predictors of UTUC recurrence in all patients and those with a smoking history. Our study population comprised 1190 NMIBC patients who underwent transurethral resection of bladder tumor. UTUC developed in 43 patients during the follow-up. A history of bacillus Calmette-Guérin (BCG) therapy was independently associated with a lower incidence of UTUC (HR = 0.43;
P
= 0.011). In a subgroup of NMIBC patients with a smoking history, concomitant carcinoma in situ (CIS) and a lower urinary pH ( |
doi_str_mv | 10.1038/s41598-021-00184-y |
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P
= 0.011). In a subgroup of NMIBC patients with a smoking history, concomitant carcinoma in situ (CIS) and a lower urinary pH (< 6) were independently associated with a higher incidence of UTUC recurrence (HR = 3.34,
P
= 0.006 and HR = 3.73,
P
= 0.008, respectively). Among patients with a longer smoking duration (≥ 20 years) or larger smoking intensity (≥ 20 cigarettes per day), those with lower urinary pH (< 6) had a significantly higher UTUC recurrence rate than their counterparts. These results suggest that BCG instillation may prevent UTUC recurrence in NMIBC patients, while a lower urinary pH and concomitant CIS increase the risk of UTUC recurrence in those with a smoking history.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-021-00184-y</identifier><identifier>PMID: 34667220</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67 ; 692/4025 ; Aged ; BCG Vaccine - therapeutic use ; Bladder cancer ; Carcinogenesis ; Carcinoma, Transitional Cell - pathology ; Cigarettes ; Female ; Humanities and Social Sciences ; Humans ; Hydrogen-Ion Concentration ; Invasiveness ; Male ; multidisciplinary ; Neoplasm Invasiveness - pathology ; Neoplasm Recurrence, Local - pathology ; pH effects ; Population studies ; Risk Factors ; Science ; Science (multidisciplinary) ; Smoking ; Smoking - pathology ; Tumors ; Ureteral Neoplasms - pathology ; Urinary Bladder Neoplasms - pathology ; Urothelial carcinoma</subject><ispartof>Scientific reports, 2021-10, Vol.11 (1), p.20675-20675, Article 20675</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-b38a33efee646d1fd81597ff057aac9644dabca18f22b7b86d1a1e513c92cff23</citedby><cites>FETCH-LOGICAL-c540t-b38a33efee646d1fd81597ff057aac9644dabca18f22b7b86d1a1e513c92cff23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2583229389/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2583229389?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25732,27903,27904,36991,36992,44569,53770,53772,74873</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34667220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ide, Hiroki</creatorcontrib><creatorcontrib>Kikuchi, Eiji</creatorcontrib><creatorcontrib>Ogihara, Koichiro</creatorcontrib><creatorcontrib>Niwa, Naoya</creatorcontrib><creatorcontrib>Shigeta, Keisuke</creatorcontrib><creatorcontrib>Masuda, Tsukasa</creatorcontrib><creatorcontrib>Baba, Yuto</creatorcontrib><creatorcontrib>Mizuno, Ryuichi</creatorcontrib><creatorcontrib>Oya, Mototsugu</creatorcontrib><title>Urinary pH is an independent predictor of upper tract recurrence in non-muscle-invasive bladder cancer patients with a smoking history</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Limited information is currently available on predictors of upper tract urothelial carcinoma (UTUC) recurrence in non-muscle-invasive bladder cancer (NMIBC) patients according to smoking history, although smoking probably contributes to urothelial carcinogenesis. Therefore, the present study aimed to identify independent predictors of UTUC recurrence in all patients and those with a smoking history. Our study population comprised 1190 NMIBC patients who underwent transurethral resection of bladder tumor. UTUC developed in 43 patients during the follow-up. A history of bacillus Calmette-Guérin (BCG) therapy was independently associated with a lower incidence of UTUC (HR = 0.43;
P
= 0.011). In a subgroup of NMIBC patients with a smoking history, concomitant carcinoma in situ (CIS) and a lower urinary pH (< 6) were independently associated with a higher incidence of UTUC recurrence (HR = 3.34,
P
= 0.006 and HR = 3.73,
P
= 0.008, respectively). Among patients with a longer smoking duration (≥ 20 years) or larger smoking intensity (≥ 20 cigarettes per day), those with lower urinary pH (< 6) had a significantly higher UTUC recurrence rate than their counterparts. These results suggest that BCG instillation may prevent UTUC recurrence in NMIBC patients, while a lower urinary pH and concomitant CIS increase the risk of UTUC recurrence in those with a smoking history.</description><subject>631/67</subject><subject>692/4025</subject><subject>Aged</subject><subject>BCG Vaccine - therapeutic use</subject><subject>Bladder cancer</subject><subject>Carcinogenesis</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Cigarettes</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Invasiveness</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>pH effects</subject><subject>Population studies</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Smoking</subject><subject>Smoking - 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therapeutic use</topic><topic>Bladder cancer</topic><topic>Carcinogenesis</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Cigarettes</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Invasiveness</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>pH effects</topic><topic>Population studies</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Smoking</topic><topic>Smoking - pathology</topic><topic>Tumors</topic><topic>Ureteral Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urothelial carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ide, Hiroki</creatorcontrib><creatorcontrib>Kikuchi, Eiji</creatorcontrib><creatorcontrib>Ogihara, Koichiro</creatorcontrib><creatorcontrib>Niwa, Naoya</creatorcontrib><creatorcontrib>Shigeta, Keisuke</creatorcontrib><creatorcontrib>Masuda, Tsukasa</creatorcontrib><creatorcontrib>Baba, Yuto</creatorcontrib><creatorcontrib>Mizuno, Ryuichi</creatorcontrib><creatorcontrib>Oya, Mototsugu</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ide, Hiroki</au><au>Kikuchi, Eiji</au><au>Ogihara, Koichiro</au><au>Niwa, Naoya</au><au>Shigeta, Keisuke</au><au>Masuda, Tsukasa</au><au>Baba, Yuto</au><au>Mizuno, Ryuichi</au><au>Oya, Mototsugu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary pH is an independent predictor of upper tract recurrence in non-muscle-invasive bladder cancer patients with a smoking history</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2021-10-19</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>20675</spage><epage>20675</epage><pages>20675-20675</pages><artnum>20675</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Limited information is currently available on predictors of upper tract urothelial carcinoma (UTUC) recurrence in non-muscle-invasive bladder cancer (NMIBC) patients according to smoking history, although smoking probably contributes to urothelial carcinogenesis. Therefore, the present study aimed to identify independent predictors of UTUC recurrence in all patients and those with a smoking history. Our study population comprised 1190 NMIBC patients who underwent transurethral resection of bladder tumor. UTUC developed in 43 patients during the follow-up. A history of bacillus Calmette-Guérin (BCG) therapy was independently associated with a lower incidence of UTUC (HR = 0.43;
P
= 0.011). In a subgroup of NMIBC patients with a smoking history, concomitant carcinoma in situ (CIS) and a lower urinary pH (< 6) were independently associated with a higher incidence of UTUC recurrence (HR = 3.34,
P
= 0.006 and HR = 3.73,
P
= 0.008, respectively). Among patients with a longer smoking duration (≥ 20 years) or larger smoking intensity (≥ 20 cigarettes per day), those with lower urinary pH (< 6) had a significantly higher UTUC recurrence rate than their counterparts. These results suggest that BCG instillation may prevent UTUC recurrence in NMIBC patients, while a lower urinary pH and concomitant CIS increase the risk of UTUC recurrence in those with a smoking history.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34667220</pmid><doi>10.1038/s41598-021-00184-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 631/67 692/4025 Aged BCG Vaccine - therapeutic use Bladder cancer Carcinogenesis Carcinoma, Transitional Cell - pathology Cigarettes Female Humanities and Social Sciences Humans Hydrogen-Ion Concentration Invasiveness Male multidisciplinary Neoplasm Invasiveness - pathology Neoplasm Recurrence, Local - pathology pH effects Population studies Risk Factors Science Science (multidisciplinary) Smoking Smoking - pathology Tumors Ureteral Neoplasms - pathology Urinary Bladder Neoplasms - pathology Urothelial carcinoma |
title | Urinary pH is an independent predictor of upper tract recurrence in non-muscle-invasive bladder cancer patients with a smoking history |
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