Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma

Asthma is a chronic inflammatory disease of the pulmonary system associated with many wheeze-to-sleep apnea complications that may lead to death. In 2019, approximately 262 million patients suffered from asthma, and 455 thousand died from the disease worldwide. It is a more severe health problem in...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-08, Vol.24 (15), p.12469
Main Authors: Kim, Min-Hee, Bae, Chun-Sik, Bok, So-Hyeon, Choi, Hyo-Seung, Ahn, Taeho, Cho, Seung-Sik, Park, Dae-Hun
Format: Article
Language:English
Subjects:
Adaptive immunity
adverse effects
Allergens
Allergies
Asthma
B cells
Children
Chronic obstructive pulmonary disease
Cytokines
Drug development
Health aspects
Hyperplasia
Immune system
Inflammation
Inflammatory diseases
Microbiota
Mortality
natural products
Neutrophils
Older people
Outdoor air quality
Pathogenesis
Pathogens
Pollutants
Respiratory agents
Respiratory system
Review
Sleep apnea syndromes
Transcription factors
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Summary:Asthma is a chronic inflammatory disease of the pulmonary system associated with many wheeze-to-sleep apnea complications that may lead to death. In 2019, approximately 262 million patients suffered from asthma, and 455 thousand died from the disease worldwide. It is a more severe health problem in children and older adults, and as the aging of society intensifies, the problem will continue to worsen. Asthma inducers can be classified as indoor and outdoor allergens and can cause asthma due to their repeated invasion. There are several theories about asthma occurrence, such as the imbalance between Th1 and Th2, inflammation in the pulmonary system, and the abnormal apoptosis/cell proliferation of cells related to asthma. Although there are many medications for asthma, as it is an incurable disease, the purpose of the drugs is only to suppress the symptoms. The current drugs can be divided into relievers and controllers; however, as they have many adverse effects, such as immune suppression, growth retardation, promotion of cataracts, hyperactivity, and convulsions, developing new asthma drugs is necessary. Although natural products can have adverse effects, the development of asthma drugs from natural products may be beneficial, as some have anti-asthmatic effects such as immune modulation, anti-inflammation, and/or apoptosis modulation.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241512469