Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII)

Dihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesized and their effects on carbonic anhydrase II (hCAII) have been evaluated. Pyrido [2,3 d] pyrimidines were synthesized from barbituric acid derivatives, malonanitrile, aldehyde derivatives in basic condition and then...

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Bibliographic Details
Published in:Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi 2021-02, Vol.25 (1), p.200-211
Main Authors: DEMİRCİ, Tuna, ÖZDEMİR, Oğuzhan, KAYA, Mustafa Oğuzhan, ARSLAN, Mustafa
Format: Article
Language:English
Subjects:
barbituric acid
carbonic anhydrase ii
dihydro 2 3 d pyridine
enaminosulfonamide
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Summary:Dihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesized and their effects on carbonic anhydrase II (hCAII) have been evaluated. Pyrido [2,3 d] pyrimidines were synthesized from barbituric acid derivatives, malonanitrile, aldehyde derivatives in basic condition and then hydrolyzed with hydrochloric acid. The targeted compounds were syn-thesized from amino sulfanilamide, dihydro [2,3D] pyridine compounds, and triethylorthoformate. 1H NMR, 13C NMR, FT-IR and elemental analysis were used for the structural analysis of the compounds. The half maximal inhibitory concentration (IC50) values of the compounds were determined to be between 27.03 and 104.39 μM for hCA II and 19.85-76.64 μM for Ki.
ISSN:2147-835X
2147-835X
DOI:10.16984/saufenbilder.688414