Association of C-reactive protein/albumin ratio with mortality in patients with Traumatic Brain Injury: A systematic review and meta-analysis

This study examines the C-reactive protein (CRP)/albumin ratio (CAR) as an inflammation-based prognostic score for predicting mortality in patients with Traumatic Brain Injury (TBI). We systematically searched the electronic databases PubMed, Embase, and Cochrane up to February 2024. Our inclusion c...

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Bibliographic Details
Published in:Heliyon 2024-07, Vol.10 (13), p.e33460, Article e33460
Main Authors: Liu, Yuyang, Tan, Yaheng, Wan, Jun, Chen, Qiwen, Zheng, Yuxin, Xu, Wenhao, Wang, Peng, Chong, Weelic, Yu, Xueying, Zhang, Yu
Format: Article
Language:English
Subjects:
albumins
brain damage
C-reactive protein
C-Reactive protein/albumin
Meta-analysis
Mortality
odds ratio
Ratio
risk assessment
statistical models
systematic review
Traumatic brain injury
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Summary:This study examines the C-reactive protein (CRP)/albumin ratio (CAR) as an inflammation-based prognostic score for predicting mortality in patients with Traumatic Brain Injury (TBI). We systematically searched the electronic databases PubMed, Embase, and Cochrane up to February 2024. Our inclusion criteria encompassed studies investigating CAR-predicted mortality in patients with TBI. We calculated the Odds Ratio (OR) and associated 95 % confidence intervals (95 % CI) using a random-effects model. Quality assessment of the included studies was appraised using a Newcastle–Ottawa scale. A total of five studies comprising 1040 patients were included in this meta-analysis. The pooled results indicated that CAR was associated with mortality in patients with TBI (OR = 1.88, 95 % CI: 1.05–3.36, P 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e33460