A pilot metabolomics study of tuberculosis immune reconstitution inflammatory syndrome

•Plasma signatures of TB immune reconstitution inflammatory syndrome (TB-IRIS) can be identified.•Arachidonic acid and glycerophospholipid metabolism pathways were perturbed in TBIRIS group.•Metabolic profiling has the potential as a new tool for early diagnosis of TB-IRIS. Diagnosis of paradoxical...

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Bibliographic Details
Published in:International journal of infectious diseases 2019-07, Vol.84, p.30-38
Main Authors: Silva, Carlos A.M., Graham, Barbara, Webb, Kristofor, Ashton, Laura Vari, Harton, Marisa, Luetkemeyer, Annie F., Bokatzian, Samantha, Almubarak, Reem, Mahapatra, Sebabrata, Hovind, Laura, Kendall, Michelle A., Havlir, Diane, Belisle, John T., De Groote, Mary Ann
Format: Article
Language:English
Subjects:
AIDS
Biosignature features
IRIS
Metabolomics
Tuberculosis
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Summary:•Plasma signatures of TB immune reconstitution inflammatory syndrome (TB-IRIS) can be identified.•Arachidonic acid and glycerophospholipid metabolism pathways were perturbed in TBIRIS group.•Metabolic profiling has the potential as a new tool for early diagnosis of TB-IRIS. Diagnosis of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is challenging and new tools are needed for early diagnosis as well as to understand the biochemical events that underlie the pathology in TB-IRIS. Plasma samples were obtained from participants from a randomized HIV/TB treatment strategy study (AIDS Clinical Trials Group [ACTG] A5221) with (n = 26) and without TB-IRIS (n = 22) for an untargeted metabolomics pilot study by liquid-chromatography mass spectrometry. The metabolic profile of these participants was compared at the study entry and as close to the diagnosis of TB-IRIS as possible (TB-IRIS window). Molecular features with p 
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2019.04.015