Continuous Blood purification on Influenza-Associated Neurological Disease in children: a retrospective cohort study

• Published in: BMC infectious diseases 2021-07, Vol.21 (1), p.1-673, Article 673
• Main Authors: Ni, Jingwen, Fang, Kenan, Zhao, Zhe, Wang, Zhiyuan, Huang, Qian, Li, Lele, Yang, Guiying, Guo, Huizi, Hong, Xiaoyang, Li, Shujun
• Format: Article
• Language: English
• Subjects: Antigens; Blood; Body weight; Cardiopulmonary resuscitation; Care and treatment; Catheters; Chi-square test; Children; Circulation, Artificial; Cohort analysis; Complications; Complications and side effects; Consciousness; Consent; Continuity (mathematics); Continuous blood purification; CPR; Diagnosis; Disease; Diseases; Epidemics; Guillain-Barre syndrome; Hospitalization; Infections; Infectious diseases; Inflammation; Influenza; Interleukin 6; Maternal & child health; Mortality; Nervous system diseases; Neurological complications; Neurological diseases; Parents & parenting; Pediatrics; Plasma; Pneumonia; Purification; Retrospective cohort study; Risk factors; Statistical analysis; Statistical tests; Survival; Veins & arteries; Ventilators; Viruses
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-021-06265-7

Due to lack of proven therapies, we evaluated the effect of CBP on Influenza-Associated Neurological Disease in children. A single-center, retrospective, cohort study was conducted in Luoyang, Henan province, China from January 2018 to January 2020. Children ( 0.05). The inflammatory factors (CRP, PCT and IL-6) of 30 cases were tested at admission and after 3 days of admission. In the CBP group, there was a significant decrease in IL-6 levels at 3 days of admission (p = 0.003) and a decrease in CRP and PCT levels, but no significant difference (p > 0.05). In the non-CBP group, there were no significant difference on levels of CRP, PCT and IL-6 at admission and 3-day of admission (p > 0.05). The 28-day mortality was significantly lower in the CBP group compared with the non-CBP group (11.11% vs. 50%, p = 0.034). CBP definitely reduces IL-6 levels significantly. We did find that the survival rate of patients in the CBP group was improved. But we don't know if there is a relationship between the reduction of IL-6 levels and the survival rate. Trial registration: http://www.chictr.org.cn/index.aspx(ChiCTR2000031754).