Association between blood pressure levels and cardiovascular deaths: a 20-year follow-up study in rural China

ObjectivesThe 2017 American College of Cardiology/American Heart Association (ACC/AHA) hypertension guideline recommended 130/80 mm Hg as blood pressure (BP) target goals. However, the generalisability of this recommendation to populations at large with hypertension remains controversial. We assesse...

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Bibliographic Details
Published in:BMJ open 2020-02, Vol.10 (2), p.e035190-e035190
Main Authors: Wang, Mengying, Wu, Tao, Yu, Canqing, Gao, Wenjing, Lv, Jun, Wu, Yiqun, Qin, Xueying, Tang, Xun, Gao, Pei, Zhan, Siyan, Cao, Weihua, Zhao, Qingshui, Huang, Shaoping, Yang, Dongli, Li, Liming, Hu, Yonghua
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Alcohol
Blood pressure
Blood Pressure Determination
Body mass index
Cardiovascular disease
China - epidemiology
Coronary Disease - complications
Coronary Disease - mortality
Diabetes
Disease prevention
Epidemiology
Family medical history
Female
Follow-Up Studies
Health surveillance
Humans
Hypertension
Hypertension - complications
Hypertension - diagnosis
Male
Middle Aged
Mortality
Multivariate Analysis
Prospective Studies
Risk Factors
Rural Health - statistics & numerical data
Smoking
Stroke
Stroke - complications
Stroke - mortality
Variables
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Summary:ObjectivesThe 2017 American College of Cardiology/American Heart Association (ACC/AHA) hypertension guideline recommended 130/80 mm Hg as blood pressure (BP) target goals. However, the generalisability of this recommendation to populations at large with hypertension remains controversial. We assessed the association between BP and cardiovascular diseases (CVDs) mortality using a 20-year follow-up study among Chinese populations.DesignProspective cohort study.Participants7314 participants were followed up for a median of 20 years in Fangshan District, Beijing, China.MethodsThe primary outcome variable was death from cardiovascular causes. The adjusted HR for CVDs mortality associated with baseline BP was calculated using Cox regression analysis.ResultsWe identified 350 deaths from CVDs (148 stroke, 113 coronary heart disease and 89 other CVDs) during follow-up. Hypertension (defined by systolic BP (SBP)/diastolic BP (DBP) ≥140/90 mm Hg) was significantly associated with mortality due to CVDs (HR=2.49, 95% CI=1.77 to 3.50) among people aged 35–59 years rather than people aged ≥60 years. In addition, there was no significant association between stage 1 hypertension defined by the 2017 ACC/AHA (SBP/DBP of 130–139/80-89 mm Hg) and CVDs mortality when compared with SBP/DBP of
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2019-035190