On the Way to Understanding the Interplay between the RNA Structure and Functions in Cells: A Genome-Wide Perspective

RNAs adopt specific structures in order to perform their biological activities. The structure of RNA is an important layer of gene expression regulation, and can impact a plethora of cellular processes, starting with transcription, RNA processing, and translation, and ending with RNA turnover. The d...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-09, Vol.21 (18), p.6770
Main Authors: Andrzejewska, Angelika, Zawadzka, Małgorzata, Pachulska-Wieczorek, Katarzyna
Format: Article
Language:English
Subjects:
Animals
Gene Expression Regulation - genetics
Genome - genetics
Genome-Wide Association Study - methods
Humans
Review
RNA - genetics
RNA binding proteome
RNA Processing, Post-Transcriptional - genetics
RNA stability and degradation
RNA structure in cells
structure-function relationship
Transcriptome - genetics
transcriptome-wide studies
translation
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Summary:RNAs adopt specific structures in order to perform their biological activities. The structure of RNA is an important layer of gene expression regulation, and can impact a plethora of cellular processes, starting with transcription, RNA processing, and translation, and ending with RNA turnover. The development of high-throughput technologies has enabled a deeper insight into the sophisticated interplay between the structure of the cellular transcriptome and the living cells environment. In this review, we present the current view on the RNA structure in vivo resulting from the most recent transcriptome-wide studies in different organisms, including mammalians, yeast, plants, and bacteria. We focus on the relationship between the mRNA structure and translation, mRNA stability and degradation, protein binding, and RNA posttranscriptional modifications.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21186770