The Emerging Roles of Ferroptosis in Vascular Cognitive Impairment

Vascular cognitive impairment (VCI) is a clinical syndrome that encompasses all forms of cognitive deficits caused by cerebrovascular disease, from mild cognitive impairment to dementia. Vascular dementia, the second most common type of dementia after Alzheimer's disease (AD), accounts for appr...

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Bibliographic Details
Published in:Frontiers in neuroscience 2019-08, Vol.13, p.811-811
Main Authors: Yan, Nao, Zhang, Jun-Jian
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal models
Apoptosis
Autophagy
Cell death
Cerebrovascular diseases
Cognitive ability
Dementia
Dementia disorders
Enzymes
Fatty acids
Ferroptosis
Homeostasis
iron dyshomeostasis
Lipid peroxidation
Lipids
Mammals
Metabolism
Neurodegenerative diseases
Neurological diseases
Neuroprotection
Neuroscience
Oxidative stress
Phagocytosis
Sexually transmitted diseases
STD
Traumatic brain injury
vascular cognitive impairment
Vascular dementia
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Summary:Vascular cognitive impairment (VCI) is a clinical syndrome that encompasses all forms of cognitive deficits caused by cerebrovascular disease, from mild cognitive impairment to dementia. Vascular dementia, the second most common type of dementia after Alzheimer's disease (AD), accounts for approximately 20% of dementia patients. Ferroptosis is a recently defined iron-dependent form of cell death, which is distinct from apoptosis, necrosis, autophagy, and other forms of cell death. Emerging evidence suggests that ferroptosis has significant implications in neurological diseases such as stroke, traumatic brain injury, and AD. Additionally, ferroptosis inhibition has an obvious neuroprotective effect and ameliorates cognitive impairment in various animal models. Here, we summarize the underlying mechanisms of ferroptosis and review the close relationship between ferroptosis and VCI.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2019.00811