Effect of the Proximity to the Quintero-Puchuncaví Industrial Zone on Compounds Isolated from Baccharis macraei Hook. & Arn: Their Antioxidant and Cytotoxic Activity

• Published in: International journal of molecular sciences 2024-06, Vol.25 (11), p.5993
• Main Authors: Martínez-Lobos, Manuel, Tapia-Venegas, Estela, Celis-Plá, Paula, Villena, Joan, Jara-Gutiérrez, Carlos, Lobos-Pessini, Alexandra, Rigano, Daniela, Sirignano, Carmina, Madrid-Villegas, Alejandro
• Format: Article
• Language: English
• Subjects: Abiotic stress; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Antioxidants; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Baccharis - chemistry; Cell Line, Tumor; Chile; Coal-fired power plants; Copper; Cytotoxicity; Flavonoids; Heavy metals; Humans; Industrial districts; Isoflavones; medicinal properties; Phenols; Photosynthesis - drug effects; Plant Extracts - chemistry; Plant Extracts - pharmacology; secondary metabolites; Sesquiterpenes; Statistical analysis
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25115993

Hook. & Arn (Asteraceae), commonly known as Vautro, is found in the coastal areas of central-southern Chile, including the industrial zone of Quintero-Puchuncaví, known for the contamination of its soils with heavy metals, which together with other factors generate abiotic stress in plant species, against which they present defensive mechanisms. For this reason, the objective was to evaluate the effect of abiotic stress generated by the proximity of to the industrial complex by assessing the physiological and metabolic states reported by the extracts and compounds isolated from the species, as well as the photosynthetic capacity, metal content and production, and antioxidant activity and cytotoxicity against tumorigenic cell lines of the phytoconstituents. To this end, was collected at two different distances from the industrial complex, observing that the closer the species is, the greater the concentration of copper in the soil, generating a decrease in the rate of electron transport in situ, but an increase in antioxidant activity with low cytotoxicity. This activity could be due to the presence of flavonoids such as Hispidulin, Cirsimaritina, and Isokaempferida, as well as monoterpenes, oxygenated and non-oxygenated sesquiterpenes identified in this study.