Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure

Micro-optical coherence tomography (µOCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic µOCT probe allowing helical luminal scanning....

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Bibliographic Details
Published in:Scientific reports 2020-06, Vol.10 (1), p.9248-9248, Article 9248
Main Authors: Kim, Junyoung, Kim, Sunwon, Song, Joon Woo, Kim, Hyun Jung, Lee, Min Woo, Han, Jeongmoo, Kim, Jin Won, Yoo, Hongki
Format: Article
Language:English
Subjects:
14/63
631/1647/245/2226
639/624/1107/510
692/4019/2776
Animals
Arteries - cytology
Arteries - diagnostic imaging
Calcinosis - complications
Cardiovascular disease
Coronary artery
Coronary vessels
Coronary Vessels - cytology
Coronary Vessels - diagnostic imaging
Endoscopy
Heart diseases
Humanities and Social Sciences
Implants
Mechanical Phenomena
Microtechnology - methods
multidisciplinary
Plaque, Atherosclerotic - complications
Plaque, Atherosclerotic - diagnostic imaging
Rabbits
Risk
Scanning
Science
Science (multidisciplinary)
Swine
Tomography
Tomography, Optical Coherence - methods
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Summary:Micro-optical coherence tomography (µOCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic µOCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic µOCT probe with an outer diameter of 1.2 mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an axial and lateral resolutions of 1.83 µm and 3.38 µm in air, respectively. Furthermore, the depth of focus of the µOCT imaging probe was extended two-fold using a binary phase spatial filter. We demonstrated that the present endoscopic µOCT could image cellular level features of a rabbit artery with high-risk atheroma and a bioresorbable scaffold-implanted swine coronary artery. This highly-translatable endoscopic µOCT will be a useful tool for investigating coronary artery disease and stent biology.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-65742-2