The Use of 99mTc-Mononuclear Leukocyte Scintigraphy for Necrotizing External Otitis Diagnosis

Background: Necrotizing external otitis (NEO) is a severe infectious disease in the external acoustic meatus (EAM) and mastoid that may extend to the cranial base. Due to the lack of a gold standard examination technique, the diagnosis is often difficult and delayed. This study aimed to evaluate the...

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Bibliographic Details
Published in:Diagnostics (Basel) 2023-02, Vol.13 (3), p.570
Main Authors: de Souza, Sergio, Laurindo, Roberta, Gutfilen-Schlesinger, Gabriel, Felix, Felippe, Amarante Junior, José, Gutfilen, Bianca
Format: Article
Language:English
Subjects:
Antibiotics
Aqueous solutions
Biopsy
Bone marrow
differential diagnosis
external otitis
Infections
leukocyte scintigraphy
Medical prognosis
Neurological disorders
Nuclear medicine
Otolaryngology
Patients
Scintigraphy
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Summary:Background: Necrotizing external otitis (NEO) is a severe infectious disease in the external acoustic meatus (EAM) and mastoid that may extend to the cranial base. Due to the lack of a gold standard examination technique, the diagnosis is often difficult and delayed. This study aimed to evaluate the sensitivity and specificity of 99mTc-mononuclear leukocyte scintigraphy associated with 99mTc-phytate in suspected NEO compared to 99mTc-MDP and 67Ga-citrate. Methods: A prospective study (32 patients) was conducted between 2011 and 2016. Results: At the end, twenty-four patients remained for the study conduction; nineteen had confirmed NEO diagnosis, one had sarcoma, one had EAM cholesteatoma, one had diffuse simple external otitis, and two had an inconclusive diagnosis. 99mTc-mononuclear leukocyte scintigraphy plus 99mTc-phytate was as sensitive as 99mTc-MDP bone scintigraphy (19/19X9/19), and more sensitive than 67Ga scintigraphy (19/19 x 17/19). Regarding specificity, it was superior to bone scintigraphy, 100% × 40% (5/5 × 2/5), and 67Ga scintigraphy, 100% × 20% (5/5 × 1/5). After the infection resolution, all NEO patients had their leukocyte scintigraphy negativized. To the best of our knowledge, this is the first study that evaluates this technique in patients with suspected NEO. Conclusions: 99mTc-mononuclear leukocyte was revealed to be the best option for NEO because of its specificity.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13030570