The effect of carbohydrates on the adherence of Pasteurella multocida to the nasal respiratory epithelium

Abstract Pasteurella multocida subsp. multocida is responsible for different diseases that generate great economic losses in farm animal. The effectiveness of immunization against those bacteria are variable and the use of antibiotics is questioned; for that reason, we investigated the potential inh...

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Bibliographic Details
Published in:Anais da Academia Brasileira de Ciências 2021-01, Vol.93 (2), p.e20190989-e20190989
Main Authors: GALLEGO, CAROLINA, PATIÑO, PILAR, MARTÍNEZ, NHORA, IREGUI, CARLOS
Format: Article
Language:English
Subjects:
Adherence
carbohydrates
lesions
MULTIDISCIPLINARY SCIENCES
Pasteurella multocida
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Summary:Abstract Pasteurella multocida subsp. multocida is responsible for different diseases that generate great economic losses in farm animal. The effectiveness of immunization against those bacteria are variable and the use of antibiotics is questioned; for that reason, we investigated the potential inhibitory effect of different carbohydrates on the adherence in vivo of P. multocida to the rabbit respiratory epithelium as an alternative for the prevention of respiratory infections. Rabbits were intranasally and intratracheally inoculated with a solution containing 200 µl of 1x107 CFU of P. multocida that was previously mixed with 250 µg /200 µl of N-acetylglucosamine, alphamethylglucoside, alphamethylmannoside, N-acetylgalactosamine or sialic acid. The animals that received N-acetylglucosamine, alphamethylglucoside or alphamethylmannoside individually or a mixture of these three carbohydrates plus the bacterium, showed a significant decrease (P
ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765202120190989