Protective Effect of Vitamins C and E on Depot-Medroxyprogesterone Acetate-Induced Ovarian Oxidative Stress In Vivo

A study was designed to investigate ameliorates effect of combined vitamins C and E able to against depot-medroxyprogesterone acetate- (DMPA-) induced ovarian oxidative stress in rat. Twenty-five female Wistar rats were divided into the following groups (n=5 rats each): control (untreated) (C); depo...

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Bibliographic Details
Published in:Journal of Toxicology 2016-01, Vol.2016 (2016), p.34-37
Main Authors: Ismiyati, Atik, Hidayati, Dwi Yuni Nur, Wiyasa, I. Wayan Arsana
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Apoptosis
Birth control
Care and treatment
Causes of
Drug dosages
Laboratories
Lipid peroxidation
Lipids
Oxidative stress
Physiological aspects
Plasma
Rodents
Studies
Vitamin C
Vitamin E
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Summary:A study was designed to investigate ameliorates effect of combined vitamins C and E able to against depot-medroxyprogesterone acetate- (DMPA-) induced ovarian oxidative stress in rat. Twenty-five female Wistar rats were divided into the following groups (n=5 rats each): control (untreated) (C); depot-medroxyprogesterone acetate (DMPA); DMPA plus green vitamin C (at dose of 0.2 mg/gram; 0.4 mg/gram; 0.8 mg/gram) and vitamin E (0.04 IU/gram). The treatment with combined vitamins C and E was performed for four weeks. Analysis of malondialdehyde (MDA) level as a marker of oxidative stress was done colorimetrically. Analysis of SOD level was done by enzyme linked immunosorbent assay (ELISA) technically. This increase in ovarium MDA was significantly (P
ISSN:1687-8191
1687-8205
DOI:10.1155/2016/3134105