Correlation of salivary neopterin and plasma fibrinogen levels in patients with chronic periodontitis and/or type 2 diabetes mellitus

Neopterin is a novel predictor for coronary events especially in diabetic patients and also an indicator for the effectiveness of the periodontal treatment. In this study, we assessed whether salivary neopterin can be used as a potential biomarker in evaluating the risk of cardiovascular disease in...

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Bibliographic Details
Published in:Pteridines 2017-12, Vol.28 (3), p.177-183
Main Authors: Fenol, Angel, Swetha, V.R., Krishnan, Sajitha, Perayil, Jayachandran, Vyloppillil, Rajesh, Bhaskar, Anuradha, Shereef, Mohammed, Balakrishnan, Biju, Puzhankara, Lakshmi
Format: Article
Language:English
Subjects:
Biomarkers
cardiovascular diseases
chronic periodontitis
Diabetes
Diabetes mellitus
diabetes mellitus type 2
Fibrinogen
Gum disease
Health risk assessment
neopterin
Patients
Reduction
Saliva
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Summary:Neopterin is a novel predictor for coronary events especially in diabetic patients and also an indicator for the effectiveness of the periodontal treatment. In this study, we assessed whether salivary neopterin can be used as a potential biomarker in evaluating the risk of cardiovascular disease in type 2 diabetic patients with chronic periodontitis. Forty subjects between 25 and 75 years of age and who matched the criteria were selected and divided into four groups. Their periodontal status was evaluated. Stimulated whole saliva and blood were collected for analysis of salivary neopterin and fibrinogen and HbA levels, respectively. Nonsurgical periodontal therapy was carried out. Patients were recalled after 3 months, and the same procedure was repeated. A reduction in all the parameters was seen after treatment in all the four groups. Salivary neopterin levels showed significant difference (p
ISSN:0933-4807
2195-4720
DOI:10.1515/pterid-2017-0007