Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ

The human iPSC cell line ZJUCHi001-A was established from renal epithelial cells present in urine (urinary cells) harvested from a 2-year-old Charcot-Marie-Tooth disease type 1B (CMT1B) patient carrying point mutation in MPZ (c.292C>T). Urinary cells were reprogrammed by retrovirus vectors contai...

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Bibliographic Details
Published in:Stem cell research 2019-03, Vol.35, p.101407-101407, Article 101407
Main Authors: Xu, Jiake, Wang, Yanpeng, He, Jing, Xia, Weichun, Zou, Yan, Ruan, Wencong, Lou, Qi, Li, Ying, Li, Haifeng, Chen, Wei
Format: Article
Language:English
Subjects:
Cell Line
Cellular Reprogramming Techniques
Charcot-Marie-Tooth Disease - genetics
Charcot-Marie-Tooth Disease - metabolism
Charcot-Marie-Tooth Disease - pathology
Child, Preschool
Humans
Induced Pluripotent Stem Cells - metabolism
Induced Pluripotent Stem Cells - pathology
Kruppel-Like Factor 4
Male
Myelin P0 Protein - genetics
Myelin P0 Protein - metabolism
Point Mutation
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Summary:The human iPSC cell line ZJUCHi001-A was established from renal epithelial cells present in urine (urinary cells) harvested from a 2-year-old Charcot-Marie-Tooth disease type 1B (CMT1B) patient carrying point mutation in MPZ (c.292C>T). Urinary cells were reprogrammed by retrovirus vectors containing reprogramming factors: OCT4, SOX2, KLF4 and c-MYC. The pluripotency, capacity of differentiation into 3 germ layers, silence of reprogramming factors and normal karyotype for this cell line were all confirmed in this study.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2019.101407