Dosimetric parameters and absolute monocyte count can predict the prognosis of acute hematologic toxicity in cervical cancer patients undergoing concurrent chemotherapy and volumetric-modulated arc therapy

To explore clinical and dosimetric predictors of acute hematologic toxicity (HT) in cervical cancer patients treated with concurrent chemotherapy and volumetric-modulated arc therapy (VMAT). We retrospectively reviewed the clinical data of 184 cervical cancer patients who had concurrent chemotherapy...

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Bibliographic Details
Published in:Radiation oncology (London, England) England), 2022-03, Vol.17 (1), p.48-48, Article 48
Main Authors: Xiang, Xiaoyong, Ding, Zhen, Zeng, Qi, Feng, Lingling, Qiu, Chunyan, Chen, Dongjie, Lu, Jiawei, Li, Ning
Format: Article
Language:English
Subjects:
Absolute monocyte count
Acute Disease
Acute hematological toxicity
Adult
Aged
Aged, 80 and over
Blood diseases
Bone marrow
Cancer
Care and treatment
Cervical cancer
Chemoradiotherapy
Chemotherapy
Combined modality therapy
Complications and side effects
Development and progression
Female
Health aspects
Hematologic Diseases - etiology
Humans
Leukocyte Count
Methods
Middle Aged
Monocytes
Oncology, Experimental
Prognosis
Radiation dosimetry
Radiometry
Radiotherapy
Radiotherapy Dosage
Radiotherapy, Intensity-Modulated - adverse effects
Retrospective Studies
Risk factors
Uterine Cervical Neoplasms - blood
Uterine Cervical Neoplasms - therapy
Volumetric-modulated arc therapy
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Summary:To explore clinical and dosimetric predictors of acute hematologic toxicity (HT) in cervical cancer patients treated with concurrent chemotherapy and volumetric-modulated arc therapy (VMAT). We retrospectively reviewed the clinical data of 184 cervical cancer patients who had concurrent chemotherapy and VMAT. Hematological parameters were collected during the treatment period. The total pelvic bone (TPB) was delineated retrospectively for dose-volume calculations. To compare the differences between two groups, the normality test findings were used to run a paired-samples t-test or Wilcoxon signed-rank test. Pearson's correlation analysis or Spearman's correlation was used to testing the correlation between the two variables. Binary logistic regression analysis was used to analyze associations between HT and possible risk factors. The receiver operating characteristic curve(ROC) was used to evaluate the best cut-off point for dosimetric planning constraints. The nadir of absolute monocyte count (AMC) was found to be positively correlated with the nadir of absolute white blood cells (WBC) count (r = 0.5378, 95% CI 0.4227-0.6357, P 
ISSN:1748-717X
1748-717X
DOI:10.1186/s13014-022-02018-1