Radix Ilicis Pubescentis total flavonoids ameliorates neuronal damage and reduces lesion extent in a mouse model of transient ischemic attack

Flavonoids are a major component in the traditional Chinese medicine Radix Ilicis Pubescentis.Previous studies have shown that the administration of Radix Ilicis Pubescentis total flavonoids is protective in cerebral ischemia.However,to our knowledge,no studies have examined whether the total flavon...

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Bibliographic Details
Published in:Neural regeneration research 2016-03, Vol.11 (3), p.441-446
Main Authors: Miao, Ming-san, Guo, Lin, Li, Rui-qi, Zhang, Xiao-lei
Format: Article
Language:English
Subjects:
Analysis
Behavior
Brain
Care and treatment
Chinese medicine
Disease
Drug dosages
Ethanol
Flavonoids
Health aspects
Isoflavones
nerve regeneration
transient ischemic attack
Radix Ilicis Pubescentis total flavonoids
tert-butyl hydroperoxide
malondialdehyde
nitric oxide
nitric oxide synthetase
superoxide dismutase
neural regeneration
Physiology
Stroke
Transient ischemic attack
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Summary:Flavonoids are a major component in the traditional Chinese medicine Radix Ilicis Pubescentis.Previous studies have shown that the administration of Radix Ilicis Pubescentis total flavonoids is protective in cerebral ischemia.However,to our knowledge,no studies have examined whether the total flavonoids extracted from Radix Ilicis Pubescentis prevent or ameliorate neuronal damage following transient ischemic attacks.Therefore,Radix Ilicis Pubescentis total flavonoids question and the potential underlying mechanisms.Thus,beginning 3 days before the induction of a mouse model of transient ischemic attack using tert-butyl hydroperoxide injections,mice were intragastrically administered 0.3,0.15,or 0.075 g/kg of Radix Ilicis Pubescentis total flavonoids daily for 10 days.The results of spectrophotometric analyses demonstrated that Radix Ilicis Pubescentis total flavonoids enhanced oxygen free radical scavenging and reduced pathological alterations in the brain.Hematoxylin-eosin staining results showed that Radix Ilicis Pubescentis total flavonoids reduced hippocampal neuronal damage and cerebral vascular injury in this mouse model of transient ischemic attack.These results suggest that the antioxidant effects of Radix Ilicis Pubescentis total flavonoids alleviate the damage to brain tissue caused by transient ischemic attack.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.179056