Lung Lesion Burden found on Chest CT as a Prognostic Marker in Hospitalized Patients with High Clinical Suspicion of COVID-19 Pneumonia: a Brazilian experience

To investigate the relationship between lung lesion burden (LLB) found on chest computed tomography (CT) and 30-day mortality in hospitalized patients with high clinical suspicion of coronavirus disease 2019 (COVID-19), accounting for tomographic dynamic changes. Patients hospitalized with high clin...

Full description

Saved in:
Bibliographic Details
Published in:Clinics (São Paulo, Brazil) Brazil), 2021, Vol.76, p.e3503-e3503, Article e3503
Main Authors: Fonseca, Eduardo Kaiser Ururahy Nunes, Assunção, Antonildes Nascimento, Araujo-Filho, Jose de Arimateia Batista, Ferreira, Lorena Carneiro, Loureiro, Bruna Melo Coelho, Strabelli, Daniel Giunchetti, Farias, Lucas de Pádua Gomes de, Chate, Rodrigo Caruso, Cerri, Giovanni Guido, Sawamura, Marcio Valente Yamada, Nomura, Cesar Higa
Format: Article
Language:English
Subjects:
COVID-19
Diagnostic Imaging
MEDICINE, GENERAL & INTERNAL
Multidetector Computed Tomography
Original
Pandemics
Pneumonia, Viral
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To investigate the relationship between lung lesion burden (LLB) found on chest computed tomography (CT) and 30-day mortality in hospitalized patients with high clinical suspicion of coronavirus disease 2019 (COVID-19), accounting for tomographic dynamic changes. Patients hospitalized with high clinical suspicion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a dedicated and reference hospital for COVID-19, having undergone at least one RT-PCR test, regardless of the result, and with one CT compatible with COVID-19, were retrospectively studied. Clinical and laboratory data upon admission were assessed, and LLB found on CT was semi-quantitatively evaluated through visual analysis. The primary outcome was 30-day mortality after admission. Secondary outcomes, including the intensive care unit (ICU) admission, mechanical ventilation used, and length of stay (LOS), were assessed. A total of 457 patients with a mean age of 57±15 years were included. Among these, 58% presented with positive RT-PCR result for COVID-19. The median time from symptom onset to RT-PCR was 8 days [interquartile range 6-11 days]. An initial LLB of ≥50% using CT was found in 201 patients (44%), which was associated with an increased crude at 30-day mortality (31% vs. 15% in patients with LLB of
ISSN:1807-5932
1980-5322
1980-5322
DOI:10.6061/clinics/2021/e3503