Drug loss while crushing tablets: Comparison of 24 tablet crushing devices

• Published in: PloS one 2018-03, Vol.13 (3), p.e0193683-e0193683
• Main Authors: Thong, Min Yew, Manrique, Yady J, Steadman, Kathryn J
• Format: Article
• Language: English
• Subjects: Acetaminophen; Analysis; Biology and Life Sciences; Dosage and administration; Drug delivery devices; Engineering and Technology; Medicine and Health Sciences; Physical Sciences
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0193683

This study investigated 24 tablet crushing devices for drug loss using different methods to recover the crushed tablet. 24 devices were compared: 3 with disposable cups, 6 with disposable bags, 12 without separate vessels and 3 types of mortar and pestle. One paracetamol tablet was crushed and recovered by tapping the powder out. Where appropriate, depending on crusher size and manufacturer instructions, the powder was also recovered by mixing with water or food. Paracetamol recovery (quantity that can be delivered to a patient) and leftover (quantity remaining in the device) were measured using a validated UV method and the entire experiment was replicated 3 times. Drug recovery ranged from 86.7-98.1% when the crushed tablet was tapped out of the crushers (average loss 5.8%). Significant losses were measured for 18 crushers, particularly manually operated hand-twist crushers with a serrated crushing surface, and some devices with disposable bags or cups. Rinsing the crushed powder with water once resulted in an average of 24.2% drug loss, and this was reduced to 4.2% after a second rinse. If crushing is unavoidable, maximizing medication delivery to the patient is essential. Rinsing twice resulted in similar paracetamol recovery to tapping the powder out; however only water rinses have the potential for direct consumption by the patient, minimizing drug loss across the entire crushing and transfer process.