Stem cell-based therapeutic strategies for rotator cuff tendinopathy

Rotator cuff tendinopathy is a common musculoskeletal disorder that imposes significant health and economic burden. Stem cell therapy has brought hope for tendon healing in patients with final stage rotator cuff tendinopathy. Some clinical trials have confirmed the effectiveness of stem cell therapy...

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Bibliographic Details
Published in:Journal of orthopaedic translation 2023-09, Vol.42, p.73-81
Main Authors: Wang, Zetao, Liao, Youguo, Wang, Canlong, Tang, Chenqi, Fang, Cailian, Luo, Junchao, Liu, Hengzhi, Mo, Xianan, Wang, Zicheng, Shen, Lingfang, Wang, Junjuan, Chen, Xiao, Yin, Zi, Li, Jianyou, Shen, Weiliang
Format: Article
Language:English
Subjects:
Clinical application
Mesenchymal stem cells
Regenerative medicine
Review
Rotator cuff
Stem cell therapy
Tendinopathy
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Summary:Rotator cuff tendinopathy is a common musculoskeletal disorder that imposes significant health and economic burden. Stem cell therapy has brought hope for tendon healing in patients with final stage rotator cuff tendinopathy. Some clinical trials have confirmed the effectiveness of stem cell therapy for rotator cuff tendinopathy, but its application has not been promoted and approved. There are still many issues that should be solved prior to using stem cell therapy in clinical applications. The optimal source and dose of stem cells for rotator cuff tendinopathy should be determined. We also proposed novel prospective approaches that can overcome cell population heterogeneity and standardize patient types for stem cell applications. [Display omitted]
ISSN:2214-031X
2214-0328
DOI:10.1016/j.jot.2023.07.006