Stem cell-based therapeutic strategies for rotator cuff tendinopathy

Rotator cuff tendinopathy is a common musculoskeletal disorder that imposes significant health and economic burden. Stem cell therapy has brought hope for tendon healing in patients with final stage rotator cuff tendinopathy. Some clinical trials have confirmed the effectiveness of stem cell therapy...

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Published in:Journal of orthopaedic translation 2023-09, Vol.42, p.73-81
Main Authors: Wang, Zetao, Liao, Youguo, Wang, Canlong, Tang, Chenqi, Fang, Cailian, Luo, Junchao, Liu, Hengzhi, Mo, Xianan, Wang, Zicheng, Shen, Lingfang, Wang, Junjuan, Chen, Xiao, Yin, Zi, Li, Jianyou, Shen, Weiliang
Format: Article
Language:English
Subjects:
Clinical application
Mesenchymal stem cells
Regenerative medicine
Review
Rotator cuff
Stem cell therapy
Tendinopathy
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cited_by cdi_FETCH-LOGICAL-c495t-67d533147c8e2746c7601650d3be0999e41b5415de7de74f70ffd70890b9ec7b3
cites cdi_FETCH-LOGICAL-c495t-67d533147c8e2746c7601650d3be0999e41b5415de7de74f70ffd70890b9ec7b3
container_end_page 81
container_issue
container_start_page 73
container_title Journal of orthopaedic translation
container_volume 42
creator Wang, Zetao
Liao, Youguo
Wang, Canlong
Tang, Chenqi
Fang, Cailian
Luo, Junchao
Liu, Hengzhi
Mo, Xianan
Wang, Zicheng
Shen, Lingfang
Wang, Junjuan
Chen, Xiao
Yin, Zi
Li, Jianyou
Shen, Weiliang
description Rotator cuff tendinopathy is a common musculoskeletal disorder that imposes significant health and economic burden. Stem cell therapy has brought hope for tendon healing in patients with final stage rotator cuff tendinopathy. Some clinical trials have confirmed the effectiveness of stem cell therapy for rotator cuff tendinopathy, but its application has not been promoted and approved. There are still many issues that should be solved prior to using stem cell therapy in clinical applications. The optimal source and dose of stem cells for rotator cuff tendinopathy should be determined. We also proposed novel prospective approaches that can overcome cell population heterogeneity and standardize patient types for stem cell applications. [Display omitted]
doi_str_mv 10.1016/j.jot.2023.07.006
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subjects Clinical application
Mesenchymal stem cells
Regenerative medicine
Review
Rotator cuff
Stem cell therapy
Tendinopathy
title Stem cell-based therapeutic strategies for rotator cuff tendinopathy
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