Designing Advanced Drug Delivery Systems: Core-Shell Alginate Particles through Electro-Fluid Dynamic Atomization

Innovations in drug delivery systems are crucial for enhancing therapeutic efficiency. Our research presents a novel approach based on using electro-fluid dynamic atomization (EFDA) to fabricate core-shell monophasic particles (CSMp) from sodium alginate blends of varying molecular weights. This stu...

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Bibliographic Details
Published in:Pharmaceutics 2024-01, Vol.16 (2), p.193
Main Authors: Cruz-Maya, Iriczalli, Schiavone, Carmine, Ferraro, Rosalia, Renkler, Nergis Zeynep, Caserta, Sergio, Guarino, Vincenzo
Format: Article
Language:English
Subjects:
Atomization
Chemical properties
Collectors
Drug delivery systems
Drugs
electro-fluid dynamic atomization
Electrodynamics
Fluid dynamics
Health aspects
Investigations
mathematical modeling
Methods
Microscopy
molecular diffusion
Morphology
Nanoparticles
Pharmaceutical industry
Pharmaceutical research
Polymers
Polysaccharides
Rheology
Sodium
sodium alginate
Vehicles
Viscoelasticity
Viscosity
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Summary:Innovations in drug delivery systems are crucial for enhancing therapeutic efficiency. Our research presents a novel approach based on using electro-fluid dynamic atomization (EFDA) to fabricate core-shell monophasic particles (CSMp) from sodium alginate blends of varying molecular weights. This study explores the morphological characteristics of these particles in relation to material properties and process conditions, highlighting their potential in drug delivery applications. A key aspect of our work is the development of a mathematical model that simulates the release kinetics of small molecules, specifically sodium diclofenac. By assessing the diffusion properties of different molecules and gel formulations through transport and rheological models, we have created a predictive tool for evaluating the efficiency of these particles in drug delivery. Our findings underscore two critical, independent parameters for optimizing drug release: the external shell thickness and the diffusivity ratios within the dual layers. This allows for precise control over the timing and intensity of the release profile. This study advances our understanding of EFDA in the fabrication of CSMp and offers promising avenues for enhancing drug delivery systems by tailoring release profiles through particle characteristic manipulation.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16020193