Ethical, legal, regulatory, and policy issues concerning embryoids: a systematic review of the literature

Recent advances in methods to culture pluripotent stem cells to model human development have resulted in entities that increasingly have recapitulated advanced stages of early embryo development. These entities, referred to by numerous terms such as embryoids, are becoming more sophisticated and cou...

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Bibliographic Details
Published in:Stem cell research & therapy 2023-08, Vol.14 (1), p.1-209, Article 209
Main Authors: Iltis, Ana S, Koster, Grace, Reeves, Emily, Matthews, Kirstin R. W
Format: Article
Language:English
Subjects:
Analysis
Cell culture
Developmental stages
Embryoids
Embryonic development
Embryos
Ethics
Interlibrary loans
Literature reviews
Pluripotency
Pluripotent stem cells
Review
Social implications
Stem cells
Synthetic embryos
Systematic review
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Summary:Recent advances in methods to culture pluripotent stem cells to model human development have resulted in entities that increasingly have recapitulated advanced stages of early embryo development. These entities, referred to by numerous terms such as embryoids, are becoming more sophisticated and could resemble human embryos ever more closely as research progresses. This paper reports a systematic review of the ethical, legal, regulatory, and policy questions and concerns found in the literature concerning human embryoid research published from 2016 to 2022. We identified 56 papers that use 53 distinct names or terms to refer to embryoids and four broad categories of ethical, legal, regulatory, or policy considerations in the literature: research justifications/benefits, ethical significance or moral status, permissible use, and regulatory and oversight challenges. Analyzing the full range of issues is a critical step toward fostering more robust ethical, legal, and social implications research in this emerging area and toward developing appropriate oversight.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-023-03448-8