Amyloid Biomarkers in Conformational Diseases at Face Value: A Systematic Review

Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, β-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as bio...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2017-12, Vol.23 (1), p.79
Main Authors: Avila-Vazquez, Maria Fernanda, Altamirano-Bustamante, Nelly F, Altamirano-Bustamante, Myriam M
Format: Article
Language:English
Subjects:
Alzheimer’s disease
Amyloid - metabolism
amyloid oligomers
Animals
biomarker
Biomarkers
Biomarkers - analysis
Chaperones
conformational diseases
cytotoxic oligomers
diabetes mellitus
Diagnostic systems
Disease
Enzyme-Linked Immunosorbent Assay
Humans
Immunoassays
Multidimensional methods
Pharmacology
Protein Aggregates
Protein Conformation
Review
Systematic review
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Summary:Conformational diseases represent a new aspect of proteomic medicine where diagnostic and therapeutic paradigms are evolving. In this context, the early biomarkers for target cell failure (neurons, β-cells, etc.) represent a challenge to translational medicine and play a multidimensional role as biomarkers and potential therapeutic targets. This systematic review, which follows the PICO and Prisma methods, analyses this new-fangled multidimensionality, its strengths and limitations, and presents the future possibilities it opens up. The nuclear diagnosis methods are immunoassays: ELISA, immunodot, western blot, etc., while the therapeutic approach is focused on pharmaco- and molecular chaperones.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules23010079