Immunohistochemical Study of ER, PR, Ki67 and p53 in Endometrial Hyperplasias and Endometrial Carcinomas

Endometrial carcinoma is the second most common gynecologic malignancy in the developing countries. Endometrial Hyperplasia (EH) is a precursor to Endometrioid Adenocarcinoma (EMAC). A 23% of Atypical Hyperplasias (AEH) progress to EMAC. This study was undertaken to analyse ER, PR, p53 and Ki67 in E...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2017-08, Vol.11 (8), p.EC31-EC34
Main Authors: Masjeed, Nayar Musfera Abdul, Khandeparkar, Siddhi Gaurish Sinai, Joshi, Avinash R, Kulkarni, Maithili Mandar, Pandya, Nidhi
Format: Article
Language:English
Subjects:
clear cell carcinoma
endometrial adenocarcinomas
serous carcinoma
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Summary:Endometrial carcinoma is the second most common gynecologic malignancy in the developing countries. Endometrial Hyperplasia (EH) is a precursor to Endometrioid Adenocarcinoma (EMAC). A 23% of Atypical Hyperplasias (AEH) progress to EMAC. This study was undertaken to analyse ER, PR, p53 and Ki67 in EH and endometrial carcinomas and attempt correlation with clinical and histopathological findings. The present study was conducted over a period of seven years. A manual tissue array technique was employed for cases subjected to IHC. Analysis of the expression of IHC markers (ER, PR, p53, Ki67) in EH and endometrial carcinoma was attempted. Results were subjected to statistical analysis. The results were considered to be significant when the p-value
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2017/28750.10475