A review of bone marrow niche cellular spectrum

To perform a narrative review on the role of bone marrow (BM) niche in normal hematopoiesis. MEDLINE databases and Ovid database were searched. The search was performed on 10 October 2018 and included articles published from 2015 to 2018 in English language. The initial search presented 45 articles,...

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Bibliographic Details
Published in:The Egyptian journal of internal medicine 2019-10, Vol.31 (4), p.397-402
Main Authors: Shoieb, Sabry A., Abdel Hafez, Mohammad A., Abd El-Hamid, Alaa E., Ezz, Walaa Hamdy
Format: Article
Language:English
Subjects:
bone marrow niche
hematopoiesis
hematopoietic stem cells
Internal Medicine
Medicine & Public Health
Review Article
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Summary:To perform a narrative review on the role of bone marrow (BM) niche in normal hematopoiesis. MEDLINE databases and Ovid database were searched. The search was performed on 10 October 2018 and included articles published from 2015 to 2018 in English language. The initial search presented 45 articles, which were included in the study. Hematopoietic stem cells which produce a variety of hematopoietic lineage cells throughout the life are located in a specialized microenvironment called the ‘niche’ in the BM where they are governed. Several types of cells in the BM have been suggested to contribute to hematopoietic stem cell niche activity.
ISSN:1110-7782
2090-9098
DOI:10.4103/ejim.ejim_68_19