Bioengineering Liver Organoids for Diseases Modelling and Transplantation

Organoids as three-dimension (3D) cellular organizations partially mimic the physiological functions and micro-architecture of native tissues and organs, holding great potential for clinical applications. Advances in the identification of essential factors including physical cues and biochemical sig...

Full description

Saved in:
Bibliographic Details
Published in:Bioengineering (Basel) 2022-12, Vol.9 (12), p.796
Main Authors: Li, Junzhi, Chu, Jing, Lui, Vincent Chi Hang, Chen, Shangsi, Chen, Yan, Tam, Paul Kwong Hang
Format: Article
Language:English
Subjects:
Bile ducts
Bioengineering
Biomaterials
Biomedical materials
Cell culture
Cell growth
Computer architecture
Disease
Engineering
Epidermal growth factor
Extracellular matrix
Fibroblasts
Growth factors
Hepatocytes
Hydrogels
Investigations
Liver
Liver cancer
liver disease models
Liver diseases
liver organoids
Mechanical properties
Morphology
Organoids
Physiological aspects
Progenitor cells
Proteins
Regenerative medicine
Review
Stem cells
Transplantation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Organoids as three-dimension (3D) cellular organizations partially mimic the physiological functions and micro-architecture of native tissues and organs, holding great potential for clinical applications. Advances in the identification of essential factors including physical cues and biochemical signals for controlling organoid development have contributed to the success of growing liver organoids from liver tissue and stem/progenitor cells. However, to recapitulate the physiological properties and the architecture of a native liver, one has to generate liver organoids that contain all the major liver cell types in correct proportions and relative 3D locations as found in a native liver. Recent advances in stem-cell-, biomaterial- and engineering-based approaches have been incorporated into conventional organoid culture methods to facilitate the development of a more sophisticated liver organoid culture resembling a near to native mini-liver in a dish. However, a comprehensive review on the recent advancement in the bioengineering liver organoid is still lacking. Here, we review the current liver organoid systems, focusing on the construction of the liver organoid system with various cell sources, the roles of growth factors for engineering liver organoids, as well as the recent advances in the bioengineering liver organoid disease models and their biomedical applications.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering9120796