Hemorrhagic shock and fluid dynamics

The measured endpoints included arteriolar and venular diameter changes, arteriolar and venular blood flow (as calculated using Poiseuille's law), and functional capillary density (FCD). Animal models always raise the issue of applicability to human physiology. [...]the authors’ negative pressu...

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Bibliographic Details
Published in:Physiological reports 2021-03, Vol.9 (6), p.e14813-n/a
Main Authors: Cohen, Maya, Monaghan, Sean F.
Format: Article
Language:English
Subjects:
Animal models
Blood
Blood flow
Edema
Hemorrhage
Hemorrhagic shock
Investigations
Physiology
Skeletal muscle
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Summary:The measured endpoints included arteriolar and venular diameter changes, arteriolar and venular blood flow (as calculated using Poiseuille's law), and functional capillary density (FCD). Animal models always raise the issue of applicability to human physiology. [...]the authors’ negative pressure device only targeted the skeletal muscle and subcutaneous tissue circulations; applying this concept to other organ systems—with heterogeneous physiologies and varying accessibility—is more theoretical than practical at this point (Govender et al., 2021). [...]this experiment isolated the effects of one treatment modality.
ISSN:2051-817X
DOI:10.14814/phy2.14813