Schizophrenia, the gut microbiota, and new opportunities from optogenetic manipulations of the gut-brain axis

• Published in: Behavioral and brain functions 2021-06, Vol.17 (1), p.7-7, Article 7
• Main Authors: Patrono, Enrico, Svoboda, Jan, Stuchlík, Aleš
• Format: Article
• Language: English
• Subjects: Alzheimer's disease; Animal models; Autism; Bacteria; Brain; Brain research; Brain-Gut Axis; Central nervous system; Cognition & reasoning; Cognitive ability; Cytokines; Emotional behavior; Enteric nervous system; Etiology; Fecal microbiota transplantation; Fecal microflora; Gastrointestinal Microbiome; Genetics; Glutamic acid receptors; Gut microbiota; Hallucinations; Humans; Hypotheses; Immune system; Infections; Information processing; Intestinal microflora; Mental disorders; Microbiota; N-Methyl-D-aspartic acid receptors; Nervous system; Neurosciences; NMDA hypoactivity; NMDARs/GABA interaction; Optics; Optogenetics; Probiotic dietaries; Probiotics; Review; Risk factors; Schizophrenia; Schizophrenia - therapy; Transplantation; γ-Aminobutyric acid
• ISSN: 1744-9081; 1744-9081
• DOI: 10.1186/s12993-021-00180-2

Schizophrenia research arose in the twentieth century and is currently rapidly developing, focusing on many parallel research pathways and evaluating various concepts of disease etiology. Today, we have relatively good knowledge about the generation of positive and negative symptoms in patients with schizophrenia. However, the neural basis and pathophysiology of schizophrenia, especially cognitive symptoms, are still poorly understood. Finding new methods to uncover the physiological basis of the mental inabilities related to schizophrenia is an urgent task for modern neuroscience because of the lack of specific therapies for cognitive deficits in the disease. Researchers have begun investigating functional crosstalk between NMDARs and GABAergic neurons associated with schizophrenia at different resolutions. In another direction, the gut microbiota is getting increasing interest from neuroscientists. Recent findings have highlighted the role of a gut-brain axis, with the gut microbiota playing a crucial role in several psychopathologies, including schizophrenia and autism.There have also been investigations into potential therapies aimed at normalizing altered microbiota signaling to the enteric nervous system (ENS) and the central nervous system (CNS). Probiotics diets and fecal microbiota transplantation (FMT) are currently the most common therapies. Interestingly, in rodent models of binge feeding, optogenetic applications have been shown to affect gut colony sensitivity, thus increasing colonic transit. Here, we review recent findings on the gut microbiota-schizophrenia relationship using in vivo optogenetics. Moreover, we evaluate if manipulating actors in either the brain or the gut might improve potential treatment research. Such research and techniques will increase our knowledge of how the gut microbiota can manipulate GABA production, and therefore accompany changes in CNS GABAergic activity.