The Interplay Between Systemic Inflammatory Factors and MicroRNAs in Age-Related Macular Degeneration

We aimed to explore the expression of systemic inflammatory factors and selected intracellular miRNAs that regulate inflammatory signaling pathways potentially involved in age-related macular degeneration (AMD) pathogenesis. A total of 179 patients with wet AMD, 175 with dry AMD and 121 controls wer...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2019-10, Vol.11, p.286-286
Main Authors: Litwińska, Zofia, Sobuś, Anna, Łuczkowska, Karolina, Grabowicz, Aleksandra, Mozolewska-Piotrowska, Katarzyna, Safranow, Krzysztof, Kawa, Miłosz Piotr, Machaliński, Bogusław, Machalińska, Anna
Format: Article
Language:English
Subjects:
Acuity
Age
Aging
Blood cells
Cell number
Chemokines
Cytokines
Disease
Granulocyte-macrophage colony-stimulating factor
IL-1β
Inflammation
interleukin
Interleukin 1
Interleukin 10
Interleukin 12
Interleukin 2
Interleukin 4
Interleukin 5
Interleukin 6
Intracellular signalling
Macular degeneration
MicroRNAs
miRNA
Multivariate analysis
Neuroscience
Neurosciences
Older people
Pathogenesis
Peripheral blood
Retina
Systematic review
Tumor necrosis factor-TNF
Tumor necrosis factor-α
γ-Interferon
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Summary:We aimed to explore the expression of systemic inflammatory factors and selected intracellular miRNAs that regulate inflammatory signaling pathways potentially involved in age-related macular degeneration (AMD) pathogenesis. A total of 179 patients with wet AMD, 175 with dry AMD and 121 controls were enrolled in the study. Soluble inflammatory factors were analyzed in plasma samples using Luminex technology. Expression of selected miRNAs was analyzed in isolated nucleated peripheral blood cells (PBNCs) using real-time qPCR. Wet AMD was an independent factor associated with higher concentrations of IL-6 (β=+0.24, p=0.0004), GM-CSF (β=+0.31, p
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2019.00286