Neisseria meningitidis Serogroup Y Sequence Type 1466 and Urogenital Infections

Neisseria meningitidis is a common commensal bacterium of the nasopharynx that can cause invasive meningococcal disease (IMD). In comparison, N. gonorrhoeae is always a pathogen usually limited to mucosal sites. However, increased evidence for overlapping clinical syndromes is emerging. We compared...

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Bibliographic Details
Published in:Emerging infectious diseases 2025-01, Vol.31 (1), p.86-93
Main Authors: van Hal, Sebastiaan J, Le, Thomas, Jenkins, Frances, Kundu, Ratan L, Limnios, E Athena, McNamara, Lucy A, Sharma, Shalabh, Kersh, Ellen N, Lahra, Monica M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Australia - epidemiology
bacteria
Child
Disease Outbreaks
Female
Humans
Keywords: Neisseria meningitidis
Male
meningitis/encephalitis
Meningococcal Infections - epidemiology
Meningococcal Infections - microbiology
Middle Aged
Neisseria gonorrhoeae
Neisseria meningitidis
Neisseria meningitidis - classification
Neisseria meningitidis - genetics
Neisseria meningitidis - isolation & purification
Neisseria meningitidis, Serogroup Y - classification
Neisseria meningitidis, Serogroup Y - genetics
Neisseria meningitidis, Serogroup Y - isolation & purification
niche adaptation
Phylogeny
United States - epidemiology
urogenital infections
Young Adult
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Summary:Neisseria meningitidis is a common commensal bacterium of the nasopharynx that can cause invasive meningococcal disease (IMD). In comparison, N. gonorrhoeae is always a pathogen usually limited to mucosal sites. However, increased evidence for overlapping clinical syndromes is emerging. We compared N. meningitidis samples from a urogenital outbreak in Australia with sequences from the United States and other countries. We conducted phylogenetic analyses to assess relatedness and examine for genomic changes associated with meningococcal adaptation; we collated a total of 255 serogroup Y (MenY), sequence type (ST) 1466 isolate assemblies. Most urogenital isolates originated from Australia; those isolates formed a distinct clade, most closely related genomically to recent US IMD isolates. No specific genomic changes suggested niche adaptation or associated clinical manifestations. The MenY ST1466 N. meningitidis isolates circulating in Australia and the United States are capable of causing both urethritis and invasive meningococcal disease.
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid3101.240940