A Meta-Analysis of GBA-Related Clinical Symptoms in Parkinson’s Disease

Background. GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the associati...

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Bibliographic Details
Published in:Parkinson's disease 2018-01, Vol.2018 (2018), p.1-7
Main Authors: Sun, Qiying, Guo, Jifeng, Xu, Qian, Pan, Hongxu, Zhou, Xun, Shu, Li, Zhang, Yuan, Tang, Bei-sha
Format: Article
Language:English
Subjects:
Computer programs
Dementia
Dementia disorders
Depression, Mental
Development and progression
Family medical history
Freezing
Glucosylceramidase
Hypotension
Meta-analysis
Movement disorders
Mutation
Neurodegenerative diseases
Parkinson's disease
Phenotypes
Review
Statistical analysis
Systematic review
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Summary:Background. GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers (GBA + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association between GBA variants and the clinical phenotypes of PD, we conducted this comprehensive meta-analysis. Method. Medline, Embase, and Cochrane were used to perform the searching. Strict selection criteria were followed in screening for new published articles or data. Revman 5.3 software was applied to perform the total statistical analysis, and funnel plots in the software were used to assess the publication biases. Results. A total of 26 articles including 931 GBA + PD and 14861 GBA noncarriers of PD (GBA − PD) were involved in the final meta-analysis, and 14 of them were either newly added publications or related data newly analyzed compared with the version published in 2015. Then, a series of symptoms containing depression, orthostatic hypotension, motor fluctuation, wearing-off, and freezing were newly analyzed due to more articles eligible. Besides, clinical features like family history, AAO, UPDRS-III, H-Y, and dementia previously analyzed were updated with new data added. Significant statistical differences were found in wearing-off, family history, AAO, UPDRS-III, and dementia (OR: 1.14, 1.65; MD: −3.61, 2.17; OR: 2.44; p: 0.03,
ISSN:2090-8083
2042-0080
DOI:10.1155/2018/3136415