Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography

• Published in: Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2019-08, Vol.13, p.1613-1620
• Main Authors: Keiner, Cathrine M, Zhou, Hao, Zhang, Qinqin, Wang, Ruikang K, Rinella, Nicholas T, Oldenburg, Catherine E, Duncan, Jacque L, Schwartz, Daniel M
• Format: Article
• Language: English
• Subjects: Algorithms; AMD; Angiography; Care and treatment; Diagnostic imaging; Flow void; Macular degeneration; Medical equipment industry; Medical imaging; Neovascularization; OCT angiography; OCTA; Original Research; Retina; Tomography; Vascular endothelial growth factor
• ISSN: 1177-5467; 1177-5483; 1177-5483
• DOI: 10.2147/OPTH.S204344

To compare choriocapillaris flow voids (FV) in patients with neovascular age-related macular degeneration (AMD) with age-matched normal controls using swept-source optical coherence tomography angiography (SS-OCTA). Eleven eyes of 11 subjects with neovascular AMD and 11 eyes of 11 age-similar normal subjects were imaged using SS-OCTA with a 6x6mm scanning pattern. Choriocapillaris FV, defined as a percentage of regions determined to have flow deficits divided by the total scanned region, was measured using a one standard deviation thresholding algorithm developed from a database of age-similar normal subjects. Choriocapillaris FV was more extensive in patients with choroidal neovascularization (CNV) compared to age-similar normal subjects (FV: 20.56±4.95, 95% CI: 17.64-23.49 vs FV: 10.95±2.08, 95% CI: 9.73-12.18, respectively; =0.0001). FV within a two-degree margin surrounding CNV in wet AMD subjects (FV: 35.04±9.34; 95% CI: 29.52-40.56) was increased compared to normal subjects (