Two Sides of the Same Coin: The Roles of KLF6 in Physiology and Pathophysiology

The Krüppel-like factors (KLFs) family of proteins control several key biological processes that include proliferation, differentiation, metabolism, apoptosis and inflammation. Dysregulation of KLF functions have been shown to disrupt cellular homeostasis and contribute to disease development. KLF6...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2020-09, Vol.10 (10), p.1378
Main Authors: Syafruddin, Saiful E, Mohtar, M Aiman, Wan Mohamad Nazarie, Wan Fahmi, Low, Teck Yew
Format: Article
Language:English
Subjects:
Alternative splicing
Amino acids
Apoptosis
cancer
Cardiovascular diseases
developmental process
Gene regulation
Genes
Growth factors
Homeostasis
inflammation
Isoforms
Kinases
KLFs
Mutation
Phosphorylation
Phylogenetics
Physiological aspects
Physiology
Post-translation
Proteins
Review
Signal transduction
transcription factor
Transcription factors
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Summary:The Krüppel-like factors (KLFs) family of proteins control several key biological processes that include proliferation, differentiation, metabolism, apoptosis and inflammation. Dysregulation of KLF functions have been shown to disrupt cellular homeostasis and contribute to disease development. KLF6 is a relevant example; a range of functional and expression assays suggested that the dysregulation of KLF6 contributes to the onset of cancer, inflammation-associated diseases as well as cardiovascular diseases. KLF6 expression is either suppressed or elevated depending on the disease, and this is largely due to alternative splicing events producing KLF6 isoforms with specialised functions. Hence, the aim of this review is to discuss the known aspects of KLF6 biology that covers the gene and protein architecture, gene regulation, post-translational modifications and functions of KLF6 in health and diseases. We put special emphasis on the equivocal roles of its full-length and spliced variants. We also deliberate on the therapeutic strategies of KLF6 and its associated signalling pathways. Finally, we provide compelling basic and clinical questions to enhance the knowledge and research on elucidating the roles of KLF6 in physiological and pathophysiological processes.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom10101378