Uniaxial and Coaxial Nanofibers PCL/Alginate or PCL/Gelatine Transport and Release Tamoxifen and Curcumin Affecting the Viability of MCF7 Cell Line

Breast cancer is the second cause of cancer death in women worldwide. The search for therapeutic and preventive alternatives has increased in recent years. One synthetic drug for patients with hormone receptor-positive tumours is tamoxifen citrate (TMX). Curcumin (Cur) is a natural compound that is...

Full description

Saved in:
Bibliographic Details
Published in:Nanomaterials (Basel, Switzerland) Switzerland), 2022-09, Vol.12 (19), p.3348
Main Authors: Suárez, Diego Fernando, Pinzón-García, Ana Delia, Sinisterra, Rubén Darío, Dussan, Anderson, Mesa, Fredy, Ramírez-Clavijo, Sandra
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Acids
Alginates
Alginic acid
Apoptosis
Breast cancer
Cancer therapies
Cell growth
Controlled release
Curcumin
Cytotoxicity
Disease
electrospinning
Infrared analysis
Infrared spectroscopy
Leukocytes (mononuclear)
MCF-7
Metastasis
nanofiber
Nanofibers
Peripheral blood
Polycaprolactone
Polymers
Product introduction
Scanning electron microscopy
Skin
Sustained release
System effectiveness
Tamoxifen
Tamoxifen citrate
Thermal analysis
Tumors
Ultraviolet spectroscopy
Womens health
X-ray diffraction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Breast cancer is the second cause of cancer death in women worldwide. The search for therapeutic and preventive alternatives has increased in recent years. One synthetic drug for patients with hormone receptor-positive tumours is tamoxifen citrate (TMX). Curcumin (Cur) is a natural compound that is being tested. Both were coupled with nanoscale-controlled and sustained release systems to increase the effectiveness of the treatment and reduce adverse effects. We produced a controlled release system based on uniaxial and coaxial polymeric nanofibers of polycaprolactone (PCL), alginate (Alg) and gelatine (Gel) for the transport and release of TMX and Cur, as a new alternative to breast cancer treatment. Nanofibers combining PCL–Alg and PCL–Gel were fabricated by the electrospinning technique and physicochemically characterised by thermal analysis, absorption spectroscopy in the infrared region and X-ray diffraction. Morphology and size were studied by scanning electron microscopy. Additionally, the release profile of TMX and Cur was obtained by UV-Vis spectroscopy. Additionally, the cytotoxic effect on breast cancer cell line MCF7 and peripheral-blood mononuclear cells (PBMCs) from a healthy donor were evaluated by a Resazurin reduction assay. These assays showed that PCL–TMX nanofiber was highly toxic to both cell types, while PCL–Cur was less toxic.
ISSN:2079-4991
2079-4991
DOI:10.3390/nano12193348