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Antiviral activities of Radix isatidis polysaccharide against pseudorabies virus in swine testicle cells
Radix isatidis has been used in China and other Asian countries for its antiviral and anti-inflammatory effects for thousands of years. However, the antiviral effect of Radix isatidis polysaccharide against pseudorabies virus (PRV) is still unknown. The polysaccharide were isolated from extract of t...
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| Published in: | BMC complementary and alternative medicine 2020-02, Vol.20 (1), p.48-48, Article 48 |
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| creator | Tong, Chao Chen, Zewen Liu, Fang Qiao, Yanyan Chen, Tong Wang, Xuebing |
| description | Radix isatidis has been used in China and other Asian countries for its antiviral and anti-inflammatory effects for thousands of years. However, the antiviral effect of Radix isatidis polysaccharide against pseudorabies virus (PRV) is still unknown.
The polysaccharide were isolated from extract of the roots of Radix isatidis. MTT assays were used to determine the preventive effect, inhibitory effect and antiviral effect of Radix isatidis polysaccharide on PRV in vitro.
This study found that different concentrations of polysaccharides from this plant can inhibit PRV replication by 14.674-30.840%, prevent infection at rates of 6.668-14.923%, and kill this virus at rates of 32.214-67.422%.
These results broaden the understanding of this traditional Chinese herb and provide a theoretical basis for further research. Moreover, Radix isatidis polysaccharide could be used for antiviral therapy. |
| doi_str_mv | 10.1186/s12906-020-2838-4 |
| format | article |
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The polysaccharide were isolated from extract of the roots of Radix isatidis. MTT assays were used to determine the preventive effect, inhibitory effect and antiviral effect of Radix isatidis polysaccharide on PRV in vitro.
This study found that different concentrations of polysaccharides from this plant can inhibit PRV replication by 14.674-30.840%, prevent infection at rates of 6.668-14.923%, and kill this virus at rates of 32.214-67.422%.
These results broaden the understanding of this traditional Chinese herb and provide a theoretical basis for further research. Moreover, Radix isatidis polysaccharide could be used for antiviral therapy.</description><identifier>ISSN: 2662-7671</identifier><identifier>EISSN: 2662-7671</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/s12906-020-2838-4</identifier><identifier>PMID: 32046705</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Acids ; Antimicrobial agents ; Antiviral agents ; Antiviral drugs ; Aujeszky's disease ; Cell culture ; Cytotoxicity ; Experiments ; Health aspects ; Herbal medicine ; Hogs ; Infection ; Infections ; Inflammation ; Influenza ; Laboratories ; Livestock ; Medical research ; Medicine ; Nervous system ; Polysaccharide ; Polysaccharides ; Pseudorabies ; Pseudorabies virus ; Radix isatidis ; Saccharides ; Statistical analysis ; Swine ; Swine testicle cells ; Viruses</subject><ispartof>BMC complementary and alternative medicine, 2020-02, Vol.20 (1), p.48-48, Article 48</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c657t-3a606ae9a1230436e59bb3ac6ce27f090e9554d49bc6ced7f59052e0dc4d46cb3</citedby><cites>FETCH-LOGICAL-c657t-3a606ae9a1230436e59bb3ac6ce27f090e9554d49bc6ced7f59052e0dc4d46cb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076820/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076820/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32046705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tong, Chao</creatorcontrib><creatorcontrib>Chen, Zewen</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Qiao, Yanyan</creatorcontrib><creatorcontrib>Chen, Tong</creatorcontrib><creatorcontrib>Wang, Xuebing</creatorcontrib><title>Antiviral activities of Radix isatidis polysaccharide against pseudorabies virus in swine testicle cells</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Med Ther</addtitle><description>Radix isatidis has been used in China and other Asian countries for its antiviral and anti-inflammatory effects for thousands of years. However, the antiviral effect of Radix isatidis polysaccharide against pseudorabies virus (PRV) is still unknown.
The polysaccharide were isolated from extract of the roots of Radix isatidis. MTT assays were used to determine the preventive effect, inhibitory effect and antiviral effect of Radix isatidis polysaccharide on PRV in vitro.
This study found that different concentrations of polysaccharides from this plant can inhibit PRV replication by 14.674-30.840%, prevent infection at rates of 6.668-14.923%, and kill this virus at rates of 32.214-67.422%.
These results broaden the understanding of this traditional Chinese herb and provide a theoretical basis for further research. Moreover, Radix isatidis polysaccharide could be used for antiviral therapy.</description><subject>Acids</subject><subject>Antimicrobial agents</subject><subject>Antiviral agents</subject><subject>Antiviral drugs</subject><subject>Aujeszky's disease</subject><subject>Cell culture</subject><subject>Cytotoxicity</subject><subject>Experiments</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Hogs</subject><subject>Infection</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Influenza</subject><subject>Laboratories</subject><subject>Livestock</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Nervous system</subject><subject>Polysaccharide</subject><subject>Polysaccharides</subject><subject>Pseudorabies</subject><subject>Pseudorabies virus</subject><subject>Radix isatidis</subject><subject>Saccharides</subject><subject>Statistical analysis</subject><subject>Swine</subject><subject>Swine testicle cells</subject><subject>Viruses</subject><issn>2662-7671</issn><issn>2662-7671</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl2L1DAYhYso7jLuD_BGAoJ40zXfaW-EYfFjYUEQvQ5vk3SaoZOMSbu6_950Z11nRHKR8PacJ-nhVNVLgi8JaeS7TGiLZY0prmnDmpo_qc6plLRWUpGnR-ez6iLnLcaYMsIUE8-rM0YxlwqL82pYh8nf-gQjArOcJu8yij36Ctb_Qj7D5K3PaB_HuwzGDJC8dQg24EOe0D672cYE3eIqmDkjH1D-6YNDk8uTN6NDxo1jflE962HM7uJhX1XfP374dvW5vvny6fpqfVMbKdRUM5BYgmuBUIY5k060XcfASOOo6nGLXSsEt7ztlpFVvWixoA5bU4bSdGxVXR-4NsJW75PfQbrTEby-H8S00ZDu36VVR6jsOk4YAC90sBT3WBpOjYFWmsJ6f2Dt527nrHFhKkGdQE-_BD_oTbzVCivZUFwAbx8AKf6YSx565_MSBwQX56wpE5xISsoTVtXrf6TbOKdQolpUikomGvFXtYHyAz70sdxrFqheS6okZ5gsqsv_qMqybudNDK73ZX5ieHNkGByM05DjOE8-hnwqJAehSTHn5PrHMAjWSy31oZa61FIvtdS8eF4dp_jo-FNC9hujad0z</recordid><startdate>20200211</startdate><enddate>20200211</enddate><creator>Tong, Chao</creator><creator>Chen, Zewen</creator><creator>Liu, Fang</creator><creator>Qiao, Yanyan</creator><creator>Chen, Tong</creator><creator>Wang, Xuebing</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200211</creationdate><title>Antiviral activities of Radix isatidis polysaccharide against pseudorabies virus in swine testicle cells</title><author>Tong, Chao ; Chen, Zewen ; Liu, Fang ; Qiao, Yanyan ; Chen, Tong ; Wang, Xuebing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c657t-3a606ae9a1230436e59bb3ac6ce27f090e9554d49bc6ced7f59052e0dc4d46cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Antimicrobial agents</topic><topic>Antiviral agents</topic><topic>Antiviral drugs</topic><topic>Aujeszky's disease</topic><topic>Cell culture</topic><topic>Cytotoxicity</topic><topic>Experiments</topic><topic>Health aspects</topic><topic>Herbal medicine</topic><topic>Hogs</topic><topic>Infection</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Influenza</topic><topic>Laboratories</topic><topic>Livestock</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Nervous system</topic><topic>Polysaccharide</topic><topic>Polysaccharides</topic><topic>Pseudorabies</topic><topic>Pseudorabies virus</topic><topic>Radix isatidis</topic><topic>Saccharides</topic><topic>Statistical analysis</topic><topic>Swine</topic><topic>Swine testicle cells</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tong, Chao</creatorcontrib><creatorcontrib>Chen, Zewen</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Qiao, Yanyan</creatorcontrib><creatorcontrib>Chen, Tong</creatorcontrib><creatorcontrib>Wang, Xuebing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tong, Chao</au><au>Chen, Zewen</au><au>Liu, Fang</au><au>Qiao, Yanyan</au><au>Chen, Tong</au><au>Wang, Xuebing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiviral activities of Radix isatidis polysaccharide against pseudorabies virus in swine testicle cells</atitle><jtitle>BMC complementary and alternative medicine</jtitle><addtitle>BMC Complement Med Ther</addtitle><date>2020-02-11</date><risdate>2020</risdate><volume>20</volume><issue>1</issue><spage>48</spage><epage>48</epage><pages>48-48</pages><artnum>48</artnum><issn>2662-7671</issn><eissn>2662-7671</eissn><eissn>1472-6882</eissn><abstract>Radix isatidis has been used in China and other Asian countries for its antiviral and anti-inflammatory effects for thousands of years. However, the antiviral effect of Radix isatidis polysaccharide against pseudorabies virus (PRV) is still unknown.
The polysaccharide were isolated from extract of the roots of Radix isatidis. MTT assays were used to determine the preventive effect, inhibitory effect and antiviral effect of Radix isatidis polysaccharide on PRV in vitro.
This study found that different concentrations of polysaccharides from this plant can inhibit PRV replication by 14.674-30.840%, prevent infection at rates of 6.668-14.923%, and kill this virus at rates of 32.214-67.422%.
These results broaden the understanding of this traditional Chinese herb and provide a theoretical basis for further research. Moreover, Radix isatidis polysaccharide could be used for antiviral therapy.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>32046705</pmid><doi>10.1186/s12906-020-2838-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | PubMed (Medline); Publicly Available Content Database |
| subjects | Acids Antimicrobial agents Antiviral agents Antiviral drugs Aujeszky's disease Cell culture Cytotoxicity Experiments Health aspects Herbal medicine Hogs Infection Infections Inflammation Influenza Laboratories Livestock Medical research Medicine Nervous system Polysaccharide Polysaccharides Pseudorabies Pseudorabies virus Radix isatidis Saccharides Statistical analysis Swine Swine testicle cells Viruses |
| title | Antiviral activities of Radix isatidis polysaccharide against pseudorabies virus in swine testicle cells |
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